Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | GFER | P55789 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.48 |
| ▸ | FPR2 | P25090 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744757 | 1.00 | KMT2A (0.54) | KMT2AGFERALDH1A1CYP2C9PYGL | |
| SCHEMBL7000160 | 0.88 | KMT2A (0.48) | KMT2AGFERALDH1A1CYP2C9PYGL | |
| SCHEMBL7000156 | 0.88 | KMT2A (0.48) | KMT2AGFERALDH1A1CYP2C9PYGL | |
| SCHEMBL8744706 | 0.88 | THRA (0.45) | KMT2AGFERCYP2C9PYGLMEN1 | |
| SCHEMBL8744704 | 0.88 | THRA (0.45) | KMT2AGFERCYP2C9PYGLMEN1 | |
| SCHEMBL9594066 | 0.86 | KMT2A (0.42) | KMT2AGFERALDH1A1CYP2C9PYGL | |
| SCHEMBL8744759 | 0.86 | KMT2A (0.42) | KMT2AGFERALDH1A1CYP2C9PYGL | |
| SCHEMBL8744745 | 0.83 | PYGL (0.48) | KMT2AGFERCYP2C9PYGLL3MBTL1 | |
| SCHEMBL8744751 | 0.83 | PYGL (0.48) | KMT2AGFERCYP2C9PYGLL3MBTL1 | |
| SCHEMBL8744760 | 0.81 | POLB (0.47) | ALDH1A1L3MBTL1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |