Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.39 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.37 |
| ▸ | VEGFA | P15692 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL769278 | 0.82 | GAA (0.48) | SMN1; SMN2GAAKDM4ENLRP3MAPT | |
| SCHEMBL4241666 | 0.79 | HPGD (0.42) | MAPTMEN1LMNAKMT2AP2RX7 | |
| SCHEMBL8874347 | 0.74 | HTT (0.39) | SMN1; SMN2NLRP3HTTNPSR1P2RX7 | |
| SCHEMBL9593911 | 0.73 | HPGD (0.36) | SMN1; SMN2NLRP3MAPTMEN1LMNA | |
| SCHEMBL8090802 | 0.73 | MAPT (0.36) | SMN1; SMN2GAAKDM4ENLRP3MAPT | |
| SCHEMBL8873539 | 0.73 | TAS1R3 (0.41) | GAAKDM4EPTGS2NLRP3MEN1 | |
| SCHEMBL8874342 | 0.72 | HPGD (0.38) | SMN1; SMN2KDM4ENLRP3MAPTMEN1 | |
| SCHEMBL15516425 | 0.72 | NLRP3 (0.46) | GAAKDM4ENLRP3MAPTMEN1 | |
| SCHEMBL7642729 | 0.72 | MAPT (0.37) | SMN1; SMN2KDM4ENLRP3MAPTMEN1 | |
| SCHEMBL6921814 | 0.71 | ALDH1A1 (0.45) | SMN1; SMN2GAAKDM4EMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |