Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SHMT1 | P34896 | 3/20 | 0.45 |
| ▸ | SHMT2 | P34897 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8744794 | 1.00 | AKR1B1 (0.53) | AKR1B1KMT2ASLC22A12ALDH1A1HPGD | |
| SCHEMBL4431531 | 0.87 | SHMT2 (0.51) | KMT2ASLC22A12ALDH1A1HPGDPOLB | |
| SCHEMBL4431529 | 0.87 | SHMT2 (0.51) | KMT2ASLC22A12ALDH1A1HPGDPOLB | |
| SCHEMBL8744816 | 0.84 | SDCBP (0.51) | AKR1B1KMT2ASLC22A12ALDH1A1HPGD | |
| SCHEMBL8744811 | 0.84 | SDCBP (0.51) | AKR1B1KMT2ASLC22A12ALDH1A1HPGD | |
| SCHEMBL9594560 | 0.82 | KMT2A (0.47) | AKR1B1KMT2ASLC22A12ALDH1A1HPGD | |
| SCHEMBL8744777 | 0.82 | KMT2A (0.47) | AKR1B1KMT2ASLC22A12ALDH1A1HPGD | |
| SCHEMBL8744785 | 0.82 | GRN (0.56) | AKR1B1KMT2ASLC22A12ALDH1A1 | |
| SCHEMBL8744789 | 0.82 | GRN (0.56) | AKR1B1KMT2ASLC22A12ALDH1A1 | |
| SCHEMBL8744730 | 0.81 | PYGL (0.47) | AKR1B1KMT2ASLC22A12ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0456063-B1 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1997-01-22 | — | — | EP | disclosed |
| US-5258527-A | Insecticidal, acaricidal and herbicidal 1-H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1993-11-02 | — | — | US | disclosed |
| EP-0456063-A2 | 1-H-3-aryl-pyrrolidin-2,4-dion-derivatives | BAYER AG (DE) | 1991-11-13 | — | — | EP | disclosed |