SCHEMBL8745144

SCHEMBL8745144

CCCCCS(=O)(=O)c1ccc(-c2cccc(S(=O)(=O)CCCCC)c2)cc1

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.47
HDAC2 Q92769 1/20 0.47
CYP3A4 P08684 3/20 0.44
CYP2C9 P11712 3/20 0.44
CYP2C19 P33261 3/20 0.44
CYP1A2 P05177 1/20 0.44
TRPV1 Q8NER1 1/20 0.44
THRB P10828 2/20 0.44
THRA P10827 1/20 0.44
ALDH1A1 P00352 1/20 0.43
CYP2D6 P10635 1/20 0.43
PTGES O14684 2/20 0.42
ALOX5 P09917 2/20 0.42
CA12 O43570 1/20 0.42
CA2 P00918 1/20 0.42
CA9 Q16790 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8920560 0.95 CYP2C9 (0.45) HDAC1HDAC2CYP3A4CYP2C9CYP2C19
SCHEMBL2703373 0.92 CYP2C9 (0.48) HDAC1HDAC2CYP3A4CYP2C9CYP2C19
SCHEMBL4630948 0.91 CYP2C9 (0.47) HDAC1HDAC2CYP3A4CYP2C9CYP2C19
SCHEMBL2704870 0.87 CYP2C9 (0.49) HDAC1HDAC2CYP3A4CYP2C9CYP2C19
SCHEMBL1243273 0.87 HDAC1 (0.58) HDAC1HDAC2CYP3A4CYP2C9CYP2C19
SCHEMBL4629380 0.85 HDAC1 (0.61) HDAC1HDAC2CYP3A4CYP2C9CYP2C19
SCHEMBL10300267 0.85 THRB (0.55) HDAC1HDAC2CYP3A4CYP2C9CYP2C19
SCHEMBL28131997 0.82 HTR6 (0.48) CYP3A4CYP2C9CYP2C19CYP1A2CYP2D6
SCHEMBL2704194 0.82 HDAC1 (0.56) HDAC1HDAC2CYP3A4CYP2C9CYP2C19
SCHEMBL17366555 0.81 CYP2C9 (0.40) HDAC1HDAC2CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0736007-A4 NON-PEPTIDE TACHYKININ RECEPTOR ANTAGONISTS LILLY CO ELI (US) 1997-03-19 EP disclosed
EP-0736007-A1 NON-PEPTIDE TACHYKININ RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1996-10-09 EP disclosed
WO-1995017382-A1 NON-PEPTIDE TACHYKININ RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1995-06-29 WO disclosed