Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MMP13 | P45452 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874023 | 0.92 | CHRNA7 (0.42) | NAMPTCHRNA7SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL874136 | 0.91 | CHRNA7 (0.40) | NAMPTCHRNA7SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL873710 | 0.90 | CHRNA7 (0.41) | NAMPTCHRNA7SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL873866 | 0.84 | CHRNA7 (0.42) | NAMPTCHRNA7SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL874059 | 0.82 | NAMPT (0.41) | NAMPTCHRNA7SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL874185 | 0.82 | NPC1 (0.39) | NAMPTCHRNA7SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL873630 | 0.81 | NAMPT (0.41) | NAMPTCHRNA7SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL874618 | 0.81 | NAMPT (0.41) | NAMPTCHRNA7SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL874535 | 0.81 | NAMPT (0.48) | NAMPTCHRNA7SMN1; SMN2HSD17B10HPGD | |
| SCHEMBL877181 | 0.80 | NAMPT (0.40) | NAMPTCHRNA7SMN1; SMN2HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |