Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874023 | 0.93 | CHRNA7 (0.42) | CHRNA7NAMPTSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL874536 | 0.90 | NAMPT (0.45) | CHRNA7NAMPTSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL874136 | 0.87 | CHRNA7 (0.40) | CHRNA7NAMPTSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL873709 | 0.83 | CHRNA7 (0.41) | CHRNA7NAMPTSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL873866 | 0.81 | CHRNA7 (0.42) | CHRNA7NAMPTSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL874185 | 0.79 | NPC1 (0.39) | CHRNA7NAMPTSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL874187 | 0.77 | NPC1 (0.46) | CHRNA7SMN1; SMN2ALDH1A1HSD17B10KDM4E | |
| SCHEMBL874680 | 0.76 | NPC1 (0.46) | SMN1; SMN2ALDH1A1HSD17B10KDM4ENPC1 | |
| SCHEMBL874022 | 0.75 | CHRNA7 (0.41) | CHRNA7NAMPTSMN1; SMN2ALDH1A1HSD17B10 | |
| SCHEMBL874535 | 0.73 | NAMPT (0.48) | CHRNA7NAMPTSMN1; SMN2ALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |