Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 7/20 | 0.34 |
| ▸ | RAB9A | P51151 | 7/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873630 | 0.85 | NAMPT (0.41) | NAMPTCHRNA7DRD2DRD3NPC1 | |
| SCHEMBL874617 | 0.82 | DRD2 (0.44) | NAMPTCHRNA7DRD2DRD3 | |
| SCHEMBL874536 | 0.81 | NAMPT (0.45) | NAMPTCHRNA7NPC1RAB9AKDM4E | |
| SCHEMBL874483 | 0.80 | RAB9A (0.40) | NAMPTCHRNA7DRD2DRD3NPC1 | |
| SCHEMBL874059 | 0.79 | NAMPT (0.41) | NAMPTCHRNA7DRD2DRD3NPC1 | |
| SCHEMBL874231 | 0.78 | CHRNA7 (0.43) | NAMPTCHRNA7DRD2DRD3NPC1 | |
| SCHEMBL877181 | 0.77 | NAMPT (0.40) | NAMPTCHRNA7DRD2DRD3KDM4E | |
| SCHEMBL875479 | 0.77 | NAMPT (0.40) | NAMPTCHRNA7DRD2DRD3NPC1 | |
| SCHEMBL874516 | 0.77 | NAMPT (0.39) | NAMPTCHRNA7NPC1RAB9AKDM4E | |
| SCHEMBL873658 | 0.76 | NAMPT (0.39) | NAMPTCHRNA7DRD2DRD3NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |