Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.61 |
| ▸ | THRA | P10827 | 8/20 | 0.61 |
| ▸ | PPARG | P37231 | 3/20 | 0.61 |
| ▸ | PCNA | P12004 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | TTR | P02766 | 2/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.51 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.51 |
| ▸ | HTR2B | P41595 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8745429 | 0.88 | THRB (0.48) | THRBTHRAPPARGPCNALMNA | |
| SCHEMBL7630334 | 0.88 | PCNA (0.72) | THRBTHRAPPARGPCNAMEN1 | |
| SCHEMBL8745418 | 0.88 | PCNA (0.72) | THRBTHRAPPARGPCNAMEN1 | |
| SCHEMBL16416000 | 0.84 | PCNA (0.79) | THRBTHRAPPARGPCNAMEN1 | |
| Hydrochloric Acid SCHEMBL3963272 | 0.83 | THRB (0.59) | THRBTHRAPPARGPCNAMEN1 | |
| SCHEMBL8745406 | 0.83 | KMT2A (0.48) | THRBTHRAPPARGKMT2AALDH1A1 | |
| SCHEMBL8745433 | 0.83 | KMT2A (0.48) | THRBTHRAPPARGKMT2AALDH1A1 | |
| SCHEMBL21803808 | 0.82 | LDHA (0.65) | PPARGPCNAADORA3HSD17B10CYP1A2 | |
| SCHEMBL21803809 | 0.82 | LDHA (0.65) | PPARGPCNAADORA3HSD17B10CYP1A2 | |
| SCHEMBL5549347 | 0.81 | THRB (0.79) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0612308-B1 | METHOD FOR PREPARING RADIO-IODINATED THYRONINE DERIVATIVES; NOVEL INTERMEDIATES | HENNING BERLIN GMBH (DE) | 1997-02-05 | — | — | EP | disclosed |
| EP-0612308-A1 | METHOD FOR PREPARING RADIO-IODINATED THYRONINE DERIVATIVES; NOVEL INTERMEDIATES. | HENNING BERLIN GMBH (DE) | 1994-08-31 | — | — | EP | disclosed |
| WO-1993009076-A1 | METHOD FOR PREPARING RADIO-IODINATED THYRONINE DERIVATIVES; NOVEL INTERMEDIATES | HENNING BERLIN GMBH CHEMIE- UND PHARMAWERK (DE) | 1993-05-13 | — | — | WO | disclosed |