Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8745599 | 0.99 | MEN1 (0.32) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL11314920 | 0.97 | MEN1 (0.31) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| Iodide SCHEMBL5229857 | 0.83 | MEN1 (0.42) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL17911707 | 0.82 | MEN1 (0.40) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| Iodide SCHEMBL8072633 | 0.75 | MEN1 (0.35) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL2845203 | 0.74 | AKR1C1 (0.45) | MEN1KMT2AALDH1A1MAPTRAB9A | |
| SCHEMBL7904469 | 0.74 | ESR1 (0.45) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| Iodide SCHEMBL7024152 | 0.74 | ALDH1A1 (0.38) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| SCHEMBL8745629 | 0.73 | MEN1 (0.36) | MEN1KMT2ANPC1ALDH1A1MAPT | |
| Iodide SCHEMBL3807575 | 0.70 | CHAT (0.37) | MEN1KMT2AALDH1A1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5693484-A | STAINING THE NUCLEIC ACIDS OF THE CELLS IN A DILUTED SAMPLE USING AN AQUEOUS SOLUTION OF A FLUORSCENT DYE, A BUFFER AND AN OSMOLARITY COMPENSATING AGENT; IRRADIATING AND MEASURING THE SCATTERED LIGHT SIGNALS | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1997-12-02 | — | — | US | claimed |
| EP-0499693-B1 | Method of differentiating erythroblasts from other cells by flow cytometry | TOA MEDICAL ELECTRONICS (JP) | 1997-02-05 | — | — | EP | claimed |
| EP-0513762-B1 | Reagent and method for analyzing cells in urine | TOA MEDICAL ELECTRONICS (JP) | 1996-09-04 | — | — | EP | claimed |
| EP-0483116-B1 | Method of classifying leukocytes by flow cytometry and reagents used in the method | TOA MEDICAL ELECTRONICS (JP) | 1996-07-17 | — | — | EP | claimed |
| EP-0485945-B1 | Method of classifying leukocytes by flow cytometry | TOA MEDICAL ELECTRONICS (JP) | 1996-06-05 | — | — | EP | claimed |
| US-5434081-A | Fluorescent dyes | TOA MEDICAL ELECTRONICS (JP) | 1995-07-18 | — | — | US | claimed |
| US-5298426-A | Method of differentiating erythroblasts from other cells by flow cytometry | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1994-03-29 | — | — | US | claimed |
| EP-0268766-B1 | METHOD OF CLASSIFYING LEUKOCYTES BY FLOW CYTOMETRY AND REAGENTS USED IN THE METHOD | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1993-06-16 | — | — | EP | claimed |
| US-5179026-A | Optical measurement on fluorochrome stained blood cell; measuring signals of right angle scattering, medical diagnosis | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1993-01-12 | — | — | US | claimed |
| EP-0513762-A1 | Reagent and method for analyzing cells in urine | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1992-11-19 | — | — | EP | claimed |
| EP-0499693-A2 | Method of differentiating erythroblasts from other cells by flow cytometry | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1992-08-26 | — | — | EP | claimed |
| EP-0259834-B1 | METHOD OF CLASSIFYING LEUCOCYTES BY FLOW CYTOMETRY | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1992-08-12 | — | — | EP | claimed |
| EP-0485945-A2 | Method of classifying leukocytes by flow cytometry | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1992-05-20 | — | — | EP | claimed |
| EP-0483116-A2 | Method of classifying leukocytes by flow cytometry and reagents used in the method | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1992-04-29 | — | — | EP | claimed |
| US-5039613-A | Using optical measurements | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1991-08-13 | — | — | US | claimed |
| US-4933293-A | IRRADIATION OF BLOOD AND DYE SOLUTION WITH A WAVELENGTH THAT EXCITES FLUORESCENCE; IDENTIFICATION BASED ON INTENSITY | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1990-06-12 | — | — | US | claimed |
| EP-0268766-A2 | Method of classifying leukocytes by flow cytometry and reagents used in the method | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1988-06-01 | — | — | EP | claimed |
| EP-0259834-A2 | Method of classifying leucocytes by flow cytometry | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1988-03-16 | — | — | EP | claimed |
| US-5693484-A | STAINING THE NUCLEIC ACIDS OF THE CELLS IN A DILUTED SAMPLE USING AN AQUEOUS SOLUTION OF A FLUORSCENT DYE, A BUFFER AND AN OSMOLARITY COMPENSATING AGENT; IRRADIATING AND MEASURING THE SCATTERED LIGHT SIGNALS | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1997-12-02 | — | — | US | disclosed |
| EP-0268766-A2 | Method of classifying leukocytes by flow cytometry and reagents used in the method | TOA MEDICAL ELECTRONICS CO., LTD. (JP) | 1988-06-01 | — | — | EP | disclosed |