Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | CKS1B | P61024 | 1/20 | 0.38 |
| ▸ | SKP1 | P63208 | 1/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.36 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.36 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22472834 | 0.79 | EPHX2 (0.59) | EPHX2KMT2AL3MBTL1KDM1AMAOB | |
| SCHEMBL19667663 | 0.76 | EPHX2 (0.43) | EPHX2KMT2AL3MBTL1GAAKDM1A | |
| SCHEMBL19054490 | 0.76 | TP53 (0.44) | EPHX2KMT2AL3MBTL1GAAKDM1A | |
| SCHEMBL28356770 | 0.74 | MTNR1A (0.45) | MTNR1ADRD2MAPT | |
| SCHEMBL31563969 | 0.73 | EPHX2 (0.42) | EPHX2KMT2AL3MBTL1GAAKDM1A | |
| SCHEMBL6068960 | 0.72 | EPHX2 (0.45) | EPHX2KMT2AL3MBTL1GAAKDM1A | |
| SCHEMBL6068965 | 0.72 | EPHX2 (0.45) | EPHX2KMT2AL3MBTL1GAAKDM1A | |
| SCHEMBL5322132 | 0.72 | KDM1A (0.44) | EPHX2KMT2AL3MBTL1GAAKDM1A | |
| SCHEMBL30799332 | 0.72 | GAA (0.52) | EPHX2KMT2AL3MBTL1GAAKDM1A | |
| SCHEMBL30954245 | 0.72 | GAA (0.46) | EPHX2KMT2AL3MBTL1GAAKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012039657-A1 | NOVEL CHROMANE COMPOUND FOR THE TREATMENT OF PAIN DISORDERS | ASTRAZENECA AB (SE) | 2012-03-29 | — | — | WO | claimed |