Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | RORB | Q92753 | 7/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874301 | 0.85 | ALDH1A1 (0.40) | ALDH1A1HPGDMAPTRORBRORC | |
| SCHEMBL11330712 | 0.85 | ALDH1A1 (0.41) | ALDH1A1HPGDMAPTRORBRORC | |
| SCHEMBL4526608 | 0.83 | ALDH1A1 (0.44) | ALDH1A1HPGDMAPTRORBRORC | |
| SCHEMBL28070522 | 0.83 | ALDH1A1 (0.41) | ALDH1A1HPGDMAPTRORBRORC | |
| Hydrazine SCHEMBL9675518 | 0.79 | ALDH1A1 (0.52) | ALDH1A1HPGDMAPTTSHRPOLB | |
| SCHEMBL6114165 | 0.79 | ALDH1A1 (0.41) | ALDH1A1HPGDMAPTRORBRORC | |
| SCHEMBL27687091 | 0.79 | ALDH1A1 (0.48) | ALDH1A1HPGDMAPTRORBRORC | |
| SCHEMBL1778181 | 0.78 | ALDH1A1 (0.55) | ALDH1A1HPGDMAPTTSHRPOLB | |
| SCHEMBL9643819 | 0.78 | MAPT (0.40) | ALDH1A1HPGDMAPTTSHRPOLB | |
| SCHEMBL873879 | 0.78 | GPR35 (0.43) | ALDH1A1HPGDMAPTTSHRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11999734-B2 | Compounds and compositions for the treatment of cystic fibrosis | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2024-06-04 | — | — | US | disclosed |
| EP-3820867-B1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | FONDAZIONE ST ITALIANO TECNOLOGIA (IT) | 2023-09-13 | — | — | EP | disclosed |
| US-20210292324-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | ISTITUTO GIANNINA GASLINI (IT) | 2021-09-23 | — | — | US | disclosed |
| CN-104844578-B | 5 membered heterocyclic amides and relevant compound | H.隆德贝克有限公司 | 2018-06-19 | — | — | CN | disclosed |
| CN-106632134-A | 2-(4-thiazolinone-2-imino)thiazole-5-carboxylate and preparation method and application thereof | 湖南大学 | 2017-05-10 | — | — | CN | disclosed |
| CN-105859707-A | (R)-N-(thiazole-2-yl)-2-[4-(quinoxaline-2-oxy) phenoxy] amide derivative and preparation method and application thereof | 河北大学 | 2016-08-17 | — | — | CN | disclosed |
| CN-105753808-A | Thiazole amide compounds, and preparation method and application thereof | 湖南化工研究院有限公司 | 2016-07-13 | — | — | CN | disclosed |
| US-9133204-B2 | 5-membered heterocyclic amides and related compounds | H. LUNDBECK A/S (DK) | 2015-09-15 | — | — | US | disclosed |
| EP-2178865-B1 | 5-MEMBERED HETEROCYCLIC AMIDES AND RELATED COMPOUNDS | LUNDBECK H AS (DK) | 2015-08-19 | — | — | EP | disclosed |
| CN-104844578-A | 5-MEMBERED HETEROCYCLIC AMIDES AND RELATED COMPOUNDS | NEUROGEN CORP | 2015-08-19 | — | — | CN | disclosed |
| CN-1764454-A | Cyclic inhibitors of protein tyrosine kinases | BRISTOL MYERS SQUIBB CO (US) | 2006-04-26 | — | — | CN | disclosed |
| CN-1348370-A | Cyclic protein tyrosine kinase inhibitors | BRISTOL MYERS SQUIBB CO (US) | 2002-05-08 | — | — | CN | disclosed |
| EP-1091958-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2001-04-18 | — | — | EP | disclosed |
| WO-2000001692-A1 | SALTS OF PAROXETINE | SMITHKLINE BEECHAM PLC (GB) | 2000-01-13 | — | — | WO | disclosed |
| US-4602454-A | PLANT SAFENING AGENTS, SEEDS CHLOROACETAMIDE HERBICIDES | MONSANTO COMPANY (US) | 1986-07-29 | — | — | US | disclosed |
| US-4602937-A | PLANT SAFENING AGENTS, ACETAMIDE HERBICIDE | MONSANTO COMPANY (US) | 1986-07-29 | — | — | US | disclosed |
| US-4586948-A | 2,4-disubstituted-5-thiazole-carboxylic acids and derivatives | MONSANTO COMPANY (US) | 1986-05-06 | — | — | US | disclosed |
| US-4437876-A | PLANT SAFENING AGENTS FOR ACETAMIDE HERBICIDES | MONSANTO COMPANY (US) | 1984-03-20 | — | — | US | disclosed |
| US-4437875-A | PLANT SAFENING AGENT FOR ACETAMIDE HERBICIDE | MONSANTO COMPANY (US) | 1984-03-20 | — | — | US | disclosed |
| US-4199506-A | REDUCES HERBICIDAL INJURY TO PLATNS DUE TO ACETAMIDE HERBICIDES | MONSANTO COMPANY (US) | 1980-04-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11999734-B2 | Compounds and compositions for the treatment of cystic fibrosis | CFTR, ABCB11, ABCC5 | ALDH1A1 2608/4885HPGD 1681/4885MAPT 4258/4885 |
| US-20210292324-A1 | COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF CYSTIC FIBROSIS | CFTR, ABCB11, ABCC5 | ALDH1A1 2608/4885HPGD 1681/4885MAPT 4258/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.