Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 1/20 | 0.44 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | IMPDH2 | P12268 | 2/20 | 0.42 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126802 | 0.93 | ALDH1A1 (0.50) | LPLLIPGCNR2ALDH1A1IMPDH2 | |
| SCHEMBL5781692 | 0.90 | CTRC (0.48) | LPLLIPGCNR2ALDH1A1IMPDH2 | |
| SCHEMBL571400 | 0.85 | — | — | |
| Acetic Acid SCHEMBL28427938 | 0.85 | CNR1 (0.45) | LPLLIPGCNR2ADORA2AMAPT | |
| Acetic Acid SCHEMBL1073868 | 0.83 | CNR1 (0.44) | LPLLIPGCNR2ADORA2AMAPT | |
| SCHEMBL28219578 | 0.82 | LPL (0.44) | LPLLIPGIMPDH2CDK8ADORA2A | |
| SCHEMBL1794873 | 0.81 | CNR1 (0.41) | LPLLIPGCNR2IMPDH2CDK8 | |
| SCHEMBL1772039 | 0.79 | LPL (0.54) | LPLLIPGALDH1A1IMPDH2CYP1A2 | |
| Formaldehyde SCHEMBL27554885 | 0.78 | CNR1 (0.42) | LPLLIPGCNR2IMPDH2CDK8 | |
| SCHEMBL5781695 | 0.76 | IMPDH2 (0.48) | CNR2ALDH1A1IMPDH2CDK8MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0755389-A1 | 3 AND 5 ALKYL AND PHENYL 4-(HYDROXY OR ACYLOXY)-ALKYL SUBSTITUTED 2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | Allergan (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028394-A1 | 3 AND 5 ALKYL AND PHENYL 4-(HYDROXY OR ACYLOXY)-ALKYL SUBSTITUTED 2(5H)-FURANONES AS ANTI-INFLAMMATORY AGENTS | ALLERGAN (US) | 1995-10-26 | — | — | WO | disclosed |
| US-5451686-A | 3 and 5 alkyl and phenyl 4-(hydroxy or acyloxy)-alkyl substituted 2(5H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1995-09-19 | — | — | US | disclosed |