Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874641 | 0.85 | LMNA (0.49) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL882909 | 0.79 | NAMPT (0.49) | KMT2AMEN1JAK2 | |
| SCHEMBL13659640 | 0.75 | MEN1 (0.50) | KMT2ANPSR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL3401326 | 0.74 | CYP1A2 (0.74) | CD274KMT2ANPSR1CYP1A2CYP2D6 | |
| SCHEMBL3408343 | 0.73 | ALDH1A1 (0.71) | CD274KMT2ANPSR1CYP1A2CYP2D6 | |
| SCHEMBL874264 | 0.70 | ALDH1A1 (0.55) | CD274KMT2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2524048 | 0.70 | KDM4E (0.46) | CD274KMT2ANPSR1ALDH1A1HSD17B10 | |
| SCHEMBL877527 | 0.69 | IKBKB (0.44) | CD274NPSR1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL14262463 | 0.68 | NPSR1 (0.50) | CHRNB2CHRNB4CHRNA3CHRNA4KMT2A | |
| SCHEMBL1186358 | 0.68 | HTR4 (0.69) | ALDH1A1HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |