Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874643 | 0.85 | CD274 (0.50) | ALDH1A1KDM4EMAPTCHRNB2CHRNB4 | |
| SCHEMBL883063 | 0.75 | MAPK1 (0.43) | ALDH1A1SMN1; SMN2HTTTDP1AR | |
| SCHEMBL10070272 | 0.75 | SLC6A3 (0.45) | ALDH1A1SMN1; SMN2KDM4EMAPTGAA | |
| SCHEMBL873644 | 0.73 | ALDH1A1 (0.61) | LMNAALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL26758003 | 0.73 | LMNA (0.60) | LMNAALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL882909 | 0.72 | NAMPT (0.49) | KMT2APOLB | |
| SCHEMBL1184898 | 0.71 | LMNA (0.58) | LMNAALDH1A1SMN1; SMN2MAPTKMT2A | |
| SCHEMBL5485425 | 0.70 | POLB (0.65) | LMNAALDH1A1SMN1; SMN2MAPTGAA | |
| SCHEMBL1841982 | 0.70 | POLB (0.55) | LMNAALDH1A1SMN1; SMN2KDM4EMAPT | |
| SCHEMBL1184262 | 0.70 | LMNA (0.59) | LMNAALDH1A1SMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |