Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874565 | 0.88 | PTPN1 (0.55) | MEN1KMT2AMAPTPTPN1APP | |
| SCHEMBL7052069 | 0.84 | IKBKB (0.55) | IKBKBMEN1KMT2APTPN1APP | |
| SCHEMBL874666 | 0.83 | IKBKB (0.55) | IKBKBMEN1KMT2AMAPTPTPN1 | |
| SCHEMBL7055593 | 0.80 | MAPT (0.52) | IKBKBMEN1KMT2AMAPTAPP | |
| SCHEMBL9243455 | 0.68 | MAPT (0.89) | MEN1KMT2AMAPTPTPN1APP | |
| SCHEMBL6229303 | 0.68 | MAPT (0.67) | IKBKBMEN1KMT2AMAPTAPP | |
| SCHEMBL18837900 | 0.67 | MAPT (0.58) | MEN1KMT2AMAPTALDH1A1POLB | |
| SCHEMBL6610018 | 0.66 | IKBKB (0.64) | IKBKBMEN1KMT2AMAPTAPP | |
| SCHEMBL875026 | 0.66 | MAPT (0.53) | IKBKBMEN1KMT2AMAPTPTPN1 | |
| SCHEMBL28895007 | 0.66 | POLB (0.53) | MEN1KMT2AMAPTRAB9AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |