Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MMP8 | P22894 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1154381 | 0.84 | ALDH1A1 (0.41) | TSHRMMP8LMNACYP1A2CYP2D6 | |
| SCHEMBL17583646 | 0.83 | CYP2D6 (0.49) | LMNACYP2D6CYP3A4GAA | |
| SCHEMBL2310025 | 0.83 | LMNA (0.62) | TSHRMMP8LMNACYP1A2CYP2D6 | |
| SCHEMBL27456672 | 0.81 | MEN1 (0.50) | TSHRMMP8LMNACYP1A2CYP2D6 | |
| SCHEMBL5530167 | 0.80 | MMP8 (0.49) | TSHRMMP8CYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL16795580 | 0.79 | MMP8 (0.49) | TSHRMMP8LMNACYP1A2SMN1; SMN2 | |
| SCHEMBL28165643 | 0.79 | CES2 (0.53) | TSHRMMP8CYP1A2SMN1; SMN2ALDH1A1 | |
| SCHEMBL26606670 | 0.79 | TSHR (0.43) | TSHRMMP8LMNACYP1A2CYP2D6 | |
| SCHEMBL22917200 | 0.78 | GAA (0.50) | GAAHDAC4HDAC3HDAC7HDAC8 | |
| SCHEMBL8707058 | 0.78 | ALDH1A1 (0.47) | TSHRMMP8LMNACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619195-A1 | HEPATITIS C VIRUS INHIBITORS | Bristol-Myers Squibb Company (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012039717-A1 | HEPATITIS C VIRUS INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-29 | — | — | WO | disclosed |