Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
| ▸ | ALPL | P05186 | 10/20 | 0.65 |
| ▸ | CA12 | O43570 | 5/20 | 0.65 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | RPA1 | P27694 | 1/20 | 0.63 |
| ▸ | CA9 | Q16790 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MARS1 | P56192 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.47 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29444429 | 0.87 | SMN1; SMN2 (0.56) | SMN1; SMN2ALPLCA12TP53RPA1 | |
| SCHEMBL29196676 | 0.83 | MAPT (0.68) | SMN1; SMN2ALPLCA9MAPTMEN1 | |
| SCHEMBL22327632 | 0.80 | SMN1; SMN2 (0.58) | SMN1; SMN2TP53MAPTMEN1NPC1 | |
| SCHEMBL9267835 | 0.80 | MAPT (0.60) | SMN1; SMN2ALPLCA12MAPTMEN1 | |
| SCHEMBL1414100 | 0.79 | ALPL (1.00) | SMN1; SMN2ALPLCA12TP53RPA1 | |
| SCHEMBL726574 | 0.79 | TP53 (1.00) | SMN1; SMN2ALPLCA12TP53RPA1 | |
| SCHEMBL12490766 | 0.78 | RAB9A (0.85) | MAPTMEN1NPC1POLBPKM | |
| SCHEMBL23803931 | 0.78 | ALPL (0.73) | SMN1; SMN2ALPLCA12TP53RPA1 | |
| SCHEMBL3447352 | 0.78 | ALPL (1.00) | ALPLCA12TP53RPA1CA9 | |
| SCHEMBL645330 | 0.78 | ALPL (1.00) | ALPLCA12TP53RPA1CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117886821-A | Nitrogen-containing condensed ring derivative inhibitor, preparation method and application thereof | 江苏豪森药业集团有限公司 | 2024-04-16 | — | — | CN | disclosed |
| CN-113754587-B | Phenylpyrazole compound and application thereof | 沈阳药科大学 | 2023-07-14 | — | — | CN | disclosed |
| CN-113754587-A | Phenylpyrazole compound and application thereof | 沈阳药科大学 | 2021-12-07 | — | — | CN | disclosed |
| WO-2012038905-A1 | THIENOPYRIDINE NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |