SCHEMBL8748154

SCHEMBL8748154

Clc1ccc(OCCOc2cc[c]cc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
ALDH3A1 P30838 1/20 0.49
MAOB P27338 3/20 0.47
DRD4 P21917 4/20 0.46
DRD2 P14416 3/20 0.46
DRD3 P35462 3/20 0.46
KCNH2 Q12809 2/20 0.46
MAOA P21397 1/20 0.45
NPC1 O15118 1/20 0.44
RAB9A P51151 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
NPSR1 Q6W5P4 1/20 0.43
LTA4H P09960 1/20 0.43
PTGS2 P35354 1/20 0.43
HRH3 Q9Y5N1 5/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7862624 0.92 ALDH3A1 (0.54) ALDH3A1DRD4DRD2DRD3KCNH2
SCHEMBL1345118 0.86 MAOB (0.57) ALDH3A1MAOBDRD4DRD2DRD3
SCHEMBL10785918 0.86 KCNA3 (0.43) DRD4DRD2DRD3
SCHEMBL832412 0.84 GPR84 (0.50) ALDH3A1MAOBKCNH2MAOANPC1
SCHEMBL5537222 0.83 KCNH2 (0.47) ALDH3A1MAOBDRD4DRD2DRD3
SCHEMBL2411188 0.79 DRD4 (0.55) ALDH3A1DRD4DRD2DRD3KCNH2
SCHEMBL11585119 0.79 DRD4 (0.53) ALDH3A1MAOBDRD4DRD2DRD3
SCHEMBL921280 0.79 KCNA3 (0.44) ALDH3A1DRD4DRD2DRD3LTA4H
SCHEMBL455696 0.79 MAOA (0.56) MAOBKCNH2MAOASMN1; SMN2LTA4H
SCHEMBL696444 0.79 MAOB (0.61) MAOBMAOANPC1RAB9ANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0534257-B1 Salicylic acid derivatives, the process for preparing the same and the heat-sensitive recording materials comprising thereof MITSUI TOATSU CHEMICALS (JP) 1997-03-12 EP disclosed
EP-0524419-B1 Heat-sensitive recording materials and phenol compounds MITSUI TOATSU CHEMICALS (JP) 1995-09-06 EP disclosed
US-5391806-A A storage stable chromogens as color-developing agent or stabilizers MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1995-02-21 US disclosed
US-5306688-A Color-forming, electron donating compound and electron accepting compound; storage stability of uncolored portion MITSUI TOATSU CHEMICALS, INC. (JP) 1994-04-26 US disclosed
US-5270281-A Chromogenic compound MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1993-12-14 US disclosed
EP-0534257-A1 Salicylic acid derivatives, the process for preparing the same and the heat-sensitive recording materials comprising thereof MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-03-31 EP disclosed
EP-0524419-A1 Heat-sensitive recording materials and phenol compounds MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-01-27 EP disclosed