SCHEMBL8748288

SCHEMBL8748288

COc1ccc(NCc2ccc(C)o2)cc1OC

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.55
ALDH1A1 P00352 7/20 0.55
KDM4E B2RXH2 6/20 0.55
GAA P10253 5/20 0.55
MEN1 O00255 2/20 0.55
KMT2A Q03164 2/20 0.55
GLA P06280 1/20 0.55
CASP1 P29466 1/20 0.55
HSD17B10 Q99714 1/20 0.55
MAPK1 P28482 4/20 0.54
POLB P06746 2/20 0.47
TDP1 Q9NUW8 2/20 0.47
L3MBTL1 Q9Y468 1/20 0.45
LMNA P02545 2/20 0.44
TP53 P04637 1/20 0.44
HIF1A Q16665 1/20 0.43
EPAS1 Q99814 1/20 0.43
GPX4 P36969 3/20 0.42
RAB9A P51151 1/20 0.42
PKM P14618 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8748534 0.85 MAPK1 (0.51) MAPTALDH1A1KDM4EGAAMEN1
SCHEMBL8748446 0.80 MAPT (0.52) MAPTALDH1A1KDM4EGAAMEN1
SCHEMBL16421379 0.78 IMPDH2 (0.54)
SCHEMBL8748209 0.75 CHRM2 (0.49) MAPTALDH1A1KDM4EGAAMEN1
SCHEMBL4093769 0.74 SMN1; SMN2 (0.60) MAPTALDH1A1KDM4EMEN1KMT2A
SCHEMBL20871233 0.73 CA2 (0.61) MAPTALDH1A1KDM4EGAAGLA
SCHEMBL30844035 0.72 NPC1 (0.51) MAPTALDH1A1KDM4EGAAMEN1
SCHEMBL5309365 0.71 HIF1A (0.63) MAPTALDH1A1KDM4EGAAMEN1
SCHEMBL2227760 0.71 ALDH1A1 (0.56) MAPTALDH1A1KDM4EGAAMEN1
SCHEMBL423387 0.71 MAPT (0.56) MAPTALDH1A1KDM4EGAAMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0761214-A2 N,N-disubstituted anilines or alkylamines as singlet oxygen quenchers, topical compositions comprising them KAO CORPORATION (JP) 1997-03-12 EP disclosed