Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1836203 | 0.84 | KDM4E (0.56) | KDM4EALDH1A1GAAHPGDLMNA | |
| Trifluoromethanesulfonic Acid SCHEMBL9694460 | 0.84 | KDM4E (0.52) | KDM4EALDH1A1GAAHPGDLMNA | |
| Bromide SCHEMBL10953017 | 0.82 | KDM4E (0.47) | KDM4EALDH1A1GAAHPGDMEN1 | |
| SCHEMBL1001565 | 0.77 | KDM4E (0.46) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL9865748 | 0.72 | KDM4E (0.46) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL4848699 | 0.70 | LMNA (0.45) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL9808014 | 0.69 | GAA (0.43) | KDM4EALDH1A1GAAHPGDLMNA | |
| 1-Ethylquinolonium SCHEMBL11069884 | 0.69 | KDM4E (0.50) | KDM4EGAALMNAHTTNPSR1 | |
| Water SCHEMBL7556226 | 0.69 | LMNA (0.44) | KDM4EALDH1A1GAAHPGDLMNA | |
| SCHEMBL3396649 | 0.68 | KDM4E (0.41) | KDM4EALDH1A1GAAHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0754967-A1 | Photographic direct positive material containing a particular stabilizer | AGFA-GEVAERT N.V. (BE) | 1997-01-22 | — | — | EP | disclosed |