Known targets — ChEMBL curated mechanism
CHRM1CHRM2CHRM3CHRM4CHRM5SLC6A2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | THPO | P40225 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11321630 | 0.86 | KDM4E (0.44) | KDM4ELMNAALDH1A1GAAHPGD | |
| SCHEMBL1836203 | 0.83 | KDM4E (0.56) | KDM4ELMNAALDH1A1GAAHPGD | |
| SCHEMBL10576427 | 0.81 | ALDH1A1 (0.47) | KDM4ELMNAALDH1A1GAAHPGD | |
| SCHEMBL9864664 | 0.76 | LMNA (0.39) | KDM4ELMNAALDH1A1GAAHPGD | |
| SCHEMBL8808254 | 0.75 | MAPT (0.51) | KDM4ELMNAALDH1A1GAAHPGD | |
| SCHEMBL2335965 | 0.74 | KDM4E (0.39) | KDM4ELMNAALDH1A1GAAHPGD | |
| 1-Ethylquinolonium SCHEMBL11069884 | 0.74 | KDM4E (0.50) | KDM4ELMNAGAAMAPTHTT | |
| SCHEMBL1833906 | 0.72 | KDM4E (0.41) | KDM4ELMNAALDH1A1GAAHPGD | |
| SCHEMBL5685535 | 0.72 | KDM4E (0.44) | KDM4ELMNAALDH1A1GAAHPGD | |
| SCHEMBL8748306 | 0.72 | KDM4E (0.51) | KDM4ELMNAALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5003077-A | Having a cycloheptimidazole nucleus; photostability; methine bond having an auxochrome | FUJI PHOTO FILM CO., LTD. (JP) | 1991-03-26 | — | — | US | disclosed |