Ammonia Solution, Strong

Ammonia Solution, Strong

SCHEMBL8748451

CCCCc1ccccc1N=O.N

nearest known ligand 0.54

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Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.54
CYP2D6 P10635 1/20 0.54
CYP2C9 P11712 1/20 0.54
LIPG Q9Y5X9 1/20 0.42
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
TLR8 Q9NR97 1/20 0.37
CTRC Q99895 1/20 0.36
BID P55957 3/20 0.36
MCL1 Q07820 3/20 0.36
BCL2L1 Q07817 2/20 0.36
BAK1 Q16611 2/20 0.36
KAT8 Q9H7Z6 2/20 0.36
PPARG P37231 1/20 0.36
PPARA Q07869 1/20 0.36
EP300 Q09472 1/20 0.36
KAT2A Q92830 1/20 0.36
KAT2B Q92831 1/20 0.36
KAT5 Q92993 1/20 0.36
SAE1 Q9UBE0 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27540250 0.98 CYP3A4 (0.56) CYP3A4CYP2D6CYP2C9LIPGNR1H2
SCHEMBL8524683 0.91 LIPG (0.53) CYP3A4CYP2D6CYP2C9LIPGNR1H2
SCHEMBL48878 0.82 CYP3A4 (0.59) CYP3A4CYP2D6CYP2C9LIPGNR1H2
SCHEMBL1032669 0.80 ALOX5 (0.49) CYP3A4CYP2D6CYP2C9BIDMCL1
SCHEMBL944030 0.79 SIGMAR1 (0.46) CYP3A4CYP2D6CYP2C9
Ammonia Solution, Strong SCHEMBL28991000 0.79 LIPG (0.54) CYP3A4CYP2D6CYP2C9LIPGNR1H2
SCHEMBL28206166 0.78 CYP3A4 (0.40) CYP3A4CYP2D6CYP2C9LIPGMCL1
SCHEMBL24389142 0.78 CYP3A4 (0.56) CYP3A4CYP2D6CYP2C9LIPGNR1H2
SCHEMBL993745 0.78 CYP3A4 (0.51) CYP3A4CYP2D6CYP2C9LIPGNR1H2
SCHEMBL29651833 0.78 CYP3A4 (0.51) CYP3A4CYP2D6CYP2C9LIPGNR1H2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0641308-B1 PROCESS FOR PREPARING N-ALIPHATIC SUBSTITUTED P-PHENYLENEDIAMINES MONSANTO CO (US) 1997-03-12 EP disclosed
EP-0641308-A1 PROCESS FOR PREPARING N-ALIPHATIC SUBSTITUTED P-PHENYLENEDIAMINES. MONSANTO CO (US) 1995-03-08 EP disclosed
WO-1993024443-A1 PROCESS FOR PREPARING N-ALIPHATIC SUBSTITUTED P-PHENYLENEDIAMINES MONSANTO COMPANY (US) 1993-12-09 WO disclosed
US-5252737-A Process for preparing N-aliphatic substituted p-phenylenediamines MONSANTO COMPANY (US) 1993-10-12 US disclosed