⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27757069 | 0.79 | — | — | |
| SCHEMBL20792669 | 0.79 | — | — | |
| SCHEMBL4550730 | 0.79 | — | — | |
| SCHEMBL370477 | 0.74 | BAZ2B (0.54) | — | |
| SCHEMBL2513855 | 0.74 | ALDH1A1 (0.51) | — | |
| SCHEMBL3579931 | 0.74 | BRD4 (0.46) | — | |
| SCHEMBL162194 | 0.73 | — | — | |
| SCHEMBL162193 | 0.73 | — | — | |
| SCHEMBL70598 | 0.73 | SMN1; SMN2 (0.62) | — | |
| SCHEMBL21712949 | 0.73 | BAZ2B (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111148734-B | Pyrrole-2-formamide compound and preparation method and application thereof | 中国医学科学院药物研究所 | 2023-01-06 | — | — | CN | disclosed |
| CN-111148734-A | Pyrrole-2-formamide compound and preparation method and application thereof | 中国医学科学院药物研究所 | 2020-05-12 | — | — | CN | disclosed |
| WO-2019042267-A1 | PYRROLE-2-FORMAMIDE COMPOUND, AND PREPARATION METHOD THEREFOR AND APPLICATIONS THEREOF | 中国医学科学院药物研究所 | 2019-03-07 | — | — | WO | disclosed |
| EP-2632469-A2 | TRICYCLIC MGLUR5 RECEPTOR MODULATORS | Merck Sharp & Dohme Corp. (US) | 2013-09-04 | — | — | EP | disclosed |
| US-20130210804-A1 | TRICYCLIC MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2013-08-15 | — | — | US | disclosed |
| US-20130210804-A1 | TRICYCLIC MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2013-08-15 | — | — | US | disclosed |
| US-20130210804-A1 | TRICYCLIC MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. | 2013-08-15 | — | — | US | disclosed |
| WO-2012172093-A1 | DIHYDROINDOLIZINE DERIVATE AS METABOTROPIC GLUTAMATE RECEPTOR MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2012-12-20 | — | — | WO | disclosed |
| WO-2012061019-A2 | TRICYCLIC MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012061019-A2 | TRICYCLIC MGLUR5 RECEPTOR MODULATORS | MERCK SHARP & DOHME CORP. (US) | 2012-05-10 | — | — | WO | disclosed |
| WO-2012038904-A1 | NICOTINAMIDE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2012-03-29 | — | — | WO | disclosed |
| EP-1090008-A4 | SYNTHESES OF A VARIETY OF LAMELLARIN COMPOUNDS AND ANALOGUES | UNIV AUSTRALIAN (AU) | 2003-01-02 | — | — | EP | disclosed |
| US-6469171-B1 | NON-TOXIC MODULATORS OF THE MULTIDRUG RESISTANT PHENOTYPE | THE AUSTRALIAN NATIONAL UNIVERSITY (AU) | 2002-10-22 | — | — | US | disclosed |
| EP-1090008-A1 | SYNTHESES OF A VARIETY OF LAMELLARIN COMPOUNDS AND ANALOGUES | THE AUSTRALIAN NATIONAL UNIVERSITY (AU) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067250-A1 | SYNTHESES OF A VARIETY OF LAMELLARIN COMPOUNDS AND ANALOGUES | THE AUSTRALIAN NATIONAL UNIVERSITY (AU) | 1999-12-29 | — | — | WO | disclosed |
| EP-0658553-B1 | Polycyclic aromatic compounds, pharmaceutical and cosmetic compositions containing them and uses thereof | CIRD GALDERMA (FR) | 1998-11-04 | — | — | EP | disclosed |
| EP-0661258-B1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CIRD GALDERMA (FR) | 1998-04-08 | — | — | EP | disclosed |
| EP-0661258-A1 | Biaromatic propynyl compounds, pharmaceutical compositions and cosmetics containing them and their uses | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-07-05 | — | — | EP | disclosed |
| EP-0658553-A1 | Polycyclic aromatic compounds, pharmaceutical compositions containing them and uses thereof | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA, ( CIRD GALDERMA) (FR) | 1995-06-21 | — | — | EP | disclosed |