Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27303798 | 0.98 | KDM1A (0.42) | KDM1AMAOBLMNAPLAU | |
| SCHEMBL27676630 | 0.79 | HTR1A (0.33) | LMNAPLAUHTR1A | |
| SCHEMBL7748228 | 0.77 | HTR1A (0.41) | LMNAHTR1A | |
| SCHEMBL27695061 | 0.77 | KDM1A (0.33) | KDM1AHTR1A | |
| SCHEMBL27676847 | 0.77 | HTR1A (0.34) | KDM1AMAOBHTR1A | |
| SCHEMBL27695429 | 0.76 | PNMT (0.33) | PLAUHTR1A | |
| SCHEMBL6003014 | 0.75 | KDM1A (0.35) | KDM1ALMNAHTR1A | |
| Hydrochloric Acid SCHEMBL27676553 | 0.75 | ACHE (0.33) | KDM1AMAOB | |
| SCHEMBL27695184 | 0.75 | ACHE (0.33) | LMNAHTR1A | |
| SCHEMBL5343873 | 0.74 | KDM1A (0.50) | KDM1AMAOBPLAU |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619187-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING DISORDERS ASSOCIATED WITH THE 5-HT1A AND 5-HT2A RECEPTORS | Aché Laboratórios Farmacêuticos S.A. (BR) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012037634-A1 | COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING DISORDERS ASSOCIATED WITH THE 5-HT1A AND 5-HT2A RECEPTORS | ACHÉ LABORATÓRIOS FARMACÊUTICOS S.A. (BR) | 2012-03-29 | — | — | WO | disclosed |
| CN-1993324-B | 3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-one derivatives and related compounds for the treatment of central nervous system disorders | EGYT GYOGYSZERVEGYESZETI GYAR | 2010-12-15 | — | — | CN | disclosed |
| CN-1993324-A | 3-(((4-phenyl)-piperazin-1-yl)-alkyl)-3-alkyl-1,3-dihydro-2h-indol-2-one derivatives and related compounds for the treatment of central nervous system disorders | EGIS GYOGYSZERGYAR NYRT (HU) | 2007-07-04 | — | — | CN | disclosed |
| US-6331636-B1 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, DIABETES, HYPERTENSION, IMPOTENCY, APPETITE CONTROL | THE UPJOHN COMPANY | 2001-12-18 | — | — | US | disclosed |
| CN-1051990-C | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and 3-aminochromones | LILLY CO ELI (US) | 2000-05-03 | — | — | CN | disclosed |
| CN-1120532-A | Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and 3-aminochromones | LILLY CO ELI (US) | 1996-04-17 | — | — | CN | disclosed |
| CN-1031262-C | Ring-substituted 2-amino-1, 2, 3, 4-tetrahydronaphthalenes and 3-aminochromanes | LILLY CO ELI (US) | 1996-03-13 | — | — | CN | disclosed |
| CN-1045099-A | Ring-substituted 2-amino-1, 2, 3, 4-tetrahydronaphthalenes and 3-aminochromanes | LILLY CO ELI (US) | 1990-09-05 | — | — | CN | disclosed |