Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 9/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 9/20 | 0.39 |
| ▸ | NPC1 | O15118 | 8/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.39 |
| ▸ | RELA | Q04206 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8633273 | 0.85 | L3MBTL1 (0.40) | NOTUMBCHEALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL27569955 | 0.78 | BCHE (0.58) | NOTUMBCHEALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL4413239 | 0.76 | NOTUM (0.47) | NOTUMBCHEL3MBTL1KMT2AMEN1 | |
| SCHEMBL4632276 | 0.76 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2CYP1A2CYP2C19TDP1 | |
| SCHEMBL27801593 | 0.76 | NOTUM (0.41) | NOTUMBCHEALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL7476038 | 0.75 | NOTUM (0.58) | NOTUMALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL8520283 | 0.74 | SMN1; SMN2 (0.39) | BCHEALDH1A1SMN1; SMN2CYP1A2CYP2C19 | |
| SCHEMBL8860170 | 0.71 | NOTUM (0.45) | NOTUMTDP1L3MBTL1KMT2AMEN1 | |
| SCHEMBL7717408 | 0.70 | MEN1 (0.51) | NOTUMALDH1A1SMN1; SMN2CYP2C19L3MBTL1 | |
| SCHEMBL16586606 | 0.69 | BCHE (0.56) | BCHEALDH1A1TDP1L3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0764152-A1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1997-03-26 | — | — | EP | disclosed |
| WO-1996032380-A1 | SUBSTITUTED INDOLYLMETHYLENE-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.P.A. (IT) | 1996-10-17 | — | — | WO | disclosed |