Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | TAOK3 | Q9H2K8 | 3/20 | 0.38 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ACE | P12821 | 2/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.36 |
| ▸ | CTSK | P43235 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8750202 | 0.85 | NOTUM (0.43) | L3MBTL1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL6306458 | 0.71 | SCN9A (0.40) | L3MBTL1 | |
| SCHEMBL7849872 | 0.71 | PSEN1 (0.48) | SMN1; SMN2NPC1RAB9ACTSKALDH1A1 | |
| SCHEMBL27569955 | 0.70 | BCHE (0.58) | L3MBTL1SMN1; SMN2ALDH1A1BCHENOTUM | |
| SCHEMBL7598202 | 0.69 | CCKBR (0.53) | — | |
| SCHEMBL7616231 | 0.69 | MME (0.42) | L3MBTL1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL6920745 | 0.67 | CCKBR (0.41) | TAOK3TAOK1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17164501 | 0.67 | CTSK (0.49) | L3MBTL1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL8520283 | 0.67 | SMN1; SMN2 (0.39) | L3MBTL1SMN1; SMN2NPC1RAB9AHPGD | |
| SCHEMBL17603549 | 0.66 | NOTUM (0.49) | L3MBTL1HPGDNOTUMLMNAPLD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0853614-A1 | SUBSTITUTED TETRALYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN S.p.A. (IT) | 1998-07-22 | — | — | EP | disclosed |
| WO-1997045409-A1 | SUBSTITUTED TETRALYLMETHYLEN-OXINDOLE ANALOGUES AS TYROSINE KINASE INHIBITORS | PHARMACIA & UPJOHN, S.P.A. (IT) | 1997-12-04 | — | — | WO | disclosed |