SCHEMBL8750404

SCHEMBL8750404

CC(Cl)c1ccc(C(C)(C)c2ccccc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 4/20 0.52
ESR2 Q92731 4/20 0.52
CYP3A4 P08684 2/20 0.52
ALDH1A1 P00352 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.43
NR3C2 P08235 3/20 0.42
CNR1 P21554 3/20 0.40
CNR2 P34972 3/20 0.40
TSHR P16473 3/20 0.38
AR P10275 1/20 0.38
HPGD P15428 1/20 0.38
SLC6A2 P23975 1/20 0.38
SLC6A4 P31645 1/20 0.38
HTR6 P50406 1/20 0.38
ESRRG P62508 1/20 0.38
SLC6A3 Q01959 1/20 0.38
HSD17B10 Q99714 1/20 0.38
KDM4E B2RXH2 2/20 0.37
TDP1 Q9NUW8 1/20 0.37
MAPK1 P28482 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6546771 0.83 ESR1 (0.56) ESR1ESR2CYP3A4ALDH1A1SMN1; SMN2
SCHEMBL22223039 0.79 ESR1 (0.52) ESR1ESR2CYP3A4ALDH1A1SMN1; SMN2
SCHEMBL8750389 0.79 ESR1 (0.57) ESR1ESR2CYP3A4ALDH1A1SMN1; SMN2
SCHEMBL7535051 0.79 ESR1 (0.75) ESR1ESR2CYP3A4ALDH1A1SMN1; SMN2
SCHEMBL8955877 0.78 TSHR (0.46) ALDH1A1TSHRHPGDHSD17B10MAPK1
SCHEMBL8750407 0.78 ALDH1A1 (0.50) ESR1ESR2CYP3A4ALDH1A1SMN1; SMN2
Hydrochloric Acid SCHEMBL2231581 0.78 PDE2A (0.53) ESR1ESR2CYP3A4ALDH1A1SMN1; SMN2
SCHEMBL213887 0.77
SCHEMBL37100 0.77
SCHEMBL14127273 0.77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0523697-B1 Color-developing compositions and their use MITSUI TOATSU CHEMICALS (JP) 1997-04-02 EP disclosed
US-5447901-A Color-developing sheet: base material coated with composition of /a/ multivalent metal-modified salicylic acid resin formed from salicylic acid, a benzyl compound and optional styrene and /b/ analogous resin free of salicylic acid MITSUI TOATSU CHEMICAL, INC. (JP) 1995-09-05 US disclosed
US-5376615-A Pressure sensitive elements containing a salicylic acid resin and a phenolic resin MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1994-12-27 US disclosed
EP-0361040-B1 Odorless multi-valent metal modified products of salicylic acid copolymers, production processes thereof, and use thereof as color-developing agents for pressure-sensitive copying paper sheets MITSUI TOATSU CHEMICALS (JP) 1994-12-07 EP disclosed
EP-0523697-A1 Color-developing compositions and their use MITSUI TOATSU CHEMICALS, Inc. (JP) 1993-01-20 EP disclosed
US-5023366-A Reacted with a benzyl halide, alcohol or ether; for pressure sensitive elements MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1991-06-11 US disclosed
EP-0361040-A2 Odorless multi-valent metal modified products of salicylic acid copolymers, production processes thereof, and use thereof as color-developing agents for pressure-sensitive copying paper sheets MITSUI TOATSU CHEMICALS, Inc. (JP) 1990-04-04 EP disclosed
EP-0268878-A2 Salicylic acid copolymers and their metal salts, production process thereof, color-developing agents comprising metal salts of the copolymers and color-developing sheets employing the agents MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-06-01 EP disclosed