SCHEMBL8750884

SCHEMBL8750884

O=C(Cl)c1ccccc1S(=O)(=O)CCCl

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
CA9 Q16790 7/20 0.42
CA1 P00915 4/20 0.42
CA2 P00918 4/20 0.42
ALDH1A1 P00352 2/20 0.41
ALOX15 P16050 1/20 0.41
APEX1 P27695 1/20 0.39
CA12 O43570 5/20 0.36
CA5A P35218 2/20 0.36
CA3 P07451 1/20 0.36
CA4 P22748 1/20 0.36
CA6 P23280 1/20 0.36
CA7 P43166 1/20 0.36
CA13 Q8N1Q1 1/20 0.36
CA14 Q9ULX7 1/20 0.36
CA5B Q9Y2D0 1/20 0.36
MMP1 P03956 1/20 0.36
MMP2 P08253 1/20 0.36
MMP9 P14780 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10944695 0.86 SMN1; SMN2 (0.62) TSHRSMN1; SMN2CA9CA1CA2
SCHEMBL10625365 0.83 APEX1 (0.38) TSHRSMN1; SMN2CA9CA1CA2
SCHEMBL8608902 0.81 TSHR (0.47) TSHRSMN1; SMN2CA9CA1CA2
SCHEMBL8982596 0.79 EPHX2 (0.48) TSHRCA9ALDH1A1CA12MMP1
SCHEMBL30675403 0.77 TSHR (0.75) TSHRSMN1; SMN2CA9CA1CA2
SCHEMBL8966630 0.77 ALDH1A1 (0.50) TSHRSMN1; SMN2CA9CA1CA2
SCHEMBL27643364 0.76 ALDH1A1 (0.44) TSHRSMN1; SMN2CA9CA1CA2
SCHEMBL8747678 0.75 ALDH1A1 (0.48) TSHRSMN1; SMN2CA9CA1CA2
SCHEMBL3645882 0.75 ALDH1A1 (0.48) TSHRSMN1; SMN2CA9CA1CA2
SCHEMBL11248541 0.73 TSHR (0.44) TSHRSMN1; SMN2CA9CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0552629-B1 Reactive dyes BAYER AG (DE) 1997-02-26 EP disclosed
US-5591834-A AZO, PHTHALOCYANINE, AND DIOXAZINE DYES FOR COTTON AND POLYAMIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-01-07 US disclosed
EP-0552629-A2 Reactive dyes BAYER AG (DE) 1993-07-28 EP disclosed