Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8751995 | 0.80 | SMN1; SMN2 (0.35) | SMN1; SMN2KMT2ARAB9AMAPTALOX15 | |
| SCHEMBL4973497 | 0.79 | L3MBTL1 (0.58) | L3MBTL1SMN1; SMN2KMT2ARAB9AMAPT | |
| SCHEMBL8752035 | 0.79 | KMT2A (0.38) | SMN1; SMN2KMT2ARAB9AMAPTALOX15 | |
| SCHEMBL16815410 | 0.78 | L3MBTL1 (0.56) | L3MBTL1SMN1; SMN2KMT2ARAB9AMAPT | |
| SCHEMBL8752043 | 0.78 | ALOX15 (0.51) | SMN1; SMN2KMT2ARAB9AMAPTALOX15 | |
| SCHEMBL8752080 | 0.77 | ALOX15 (0.31) | KMT2AALOX15 | |
| SCHEMBL8752023 | 0.76 | ALDH1A1 (0.41) | L3MBTL1KMT2ARAB9AMAPTALOX15 | |
| SCHEMBL5928189 | 0.76 | ALDH1A1 (0.33) | L3MBTL1KMT2AALOX15NPSR1ALDH1A1 | |
| SCHEMBL8752048 | 0.76 | MAPK1 (0.32) | L3MBTL1SMN1; SMN2KMT2ARAB9AMAPT | |
| SCHEMBL16815611 | 0.76 | L3MBTL1 (0.54) | L3MBTL1SMN1; SMN2KMT2ARAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684011-A | Pyrimidine derivatives useful as nematicides | ZENECA LIMITED (GB) | 1997-11-04 | — | — | US | disclosed |
| EP-0660827-B1 | HETEROCYCLIC COMPOUNDS WITH PARASITICAL ACTIVITY | ZENECA LTD (GB) | 1997-04-16 | — | — | EP | disclosed |
| EP-0660827-A1 | HETEROCYCLIC COMPOUNDS WIHT PARASITICAL ACTIVITY. | ZENECA LTD (GB) | 1995-07-05 | — | — | EP | disclosed |
| WO-1994006777-A1 | HETEROCYCLIC COMPOUNDS WIHT PARASITICAL ACTIVITY | ZENECA LIMITED (GB) | 1994-03-31 | — | — | WO | disclosed |