Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRSS1 | P07477 | 2/20 | 0.35 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.35 |
| ▸ | F7 | P08709 | 2/20 | 0.35 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ULK1 | O75385 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 4/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.33 |
| ▸ | AURKA | O14965 | 3/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.33 |
| ▸ | IGF1R | P08069 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CDK1 | P06493 | 2/20 | 0.33 |
| ▸ | KIT | P10721 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL876287 | 0.85 | MAPT (0.35) | RXFP1KMT2ATP53MAPTUSP7 | |
| SCHEMBL875250 | 0.83 | RORC (0.38) | RXFP1KMT2ATP53MAPTUSP7 | |
| SCHEMBL883352 | 0.79 | KCNQ3 (0.37) | PRSS1PRSS2F7PRSS3RXFP1 | |
| SCHEMBL875789 | 0.73 | LMNA (0.42) | KMT2ATP53MAPT | |
| SCHEMBL875212 | 0.70 | GUCY1B2 (0.34) | KMT2AMAPT | |
| SCHEMBL875780 | 0.67 | KDM4E (0.49) | RXFP1KMT2ATP53MAPT | |
| SCHEMBL15887182 | 0.66 | NPC1 (0.39) | TP53MAPTAURKACDK1SYK | |
| SCHEMBL883428 | 0.65 | SMN1; SMN2 (0.40) | RXFP1TP53MAPT | |
| SCHEMBL876306 | 0.65 | SMN1; SMN2 (0.40) | RXFP1KMT2ATP53MAPTUSP7 | |
| SCHEMBL2217034 | 0.64 | STK10 (0.42) | KMT2AMAPTCDK1SYKSLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619202-A1 | PYRIDMIDONES FOR TREATMENT OF POTASSIUM CHANNEL RELATED DISEASES | Pfizer Inc (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038850-A1 | PYRIDMIDONES FOR TREATMENT OF POTASSIUM CHANNEL RELATED DISEASES | PFIZER INC. (US) | 2012-03-29 | — | — | WO | disclosed |