Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | USP7 | Q93009 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875789 | 0.87 | LMNA (0.42) | MAPTTP53KMT2AMEN1RCE1 | |
| SCHEMBL875508 | 0.85 | PRSS1 (0.35) | MAPTTP53USP7KMT2ARXFP1 | |
| SCHEMBL875250 | 0.80 | RORC (0.38) | MAPTTP53USP7CYP2C9CYP1A2 | |
| SCHEMBL876306 | 0.77 | SMN1; SMN2 (0.40) | MAPTTP53USP7CYP2C9CYP1A2 | |
| SCHEMBL875780 | 0.70 | KDM4E (0.49) | MAPTTP53POLBKMT2AMEN1 | |
| SCHEMBL15887182 | 0.69 | NPC1 (0.39) | MAPTTP53NR1H3CYP2C9CYP1A2 | |
| SCHEMBL875212 | 0.67 | GUCY1B2 (0.34) | MAPTKMT2AMEN1 | |
| SCHEMBL2217034 | 0.66 | STK10 (0.42) | MAPTKMT2AMEN1 | |
| SCHEMBL883352 | 0.65 | KCNQ3 (0.37) | MAPTTP53CYP2C9CYP1A2KMT2A | |
| SCHEMBL875449 | 0.64 | SMN1; SMN2 (0.42) | MAPTTP53USP7CYP2C9CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619202-A1 | PYRIDMIDONES FOR TREATMENT OF POTASSIUM CHANNEL RELATED DISEASES | Pfizer Inc (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038850-A1 | PYRIDMIDONES FOR TREATMENT OF POTASSIUM CHANNEL RELATED DISEASES | PFIZER INC. (US) | 2012-03-29 | — | — | WO | disclosed |