Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | CASP1 | P29466 | 3/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL875789 | 0.82 | LMNA (0.42) | KDM4EMAPTNPSR1HSD17B10CASP1 | |
| SCHEMBL875494 | 0.72 | KDM4E (0.50) | KDM4EMAPTNPSR1RECQLHSD17B10 | |
| SCHEMBL2217810 | 0.72 | KDM4E (0.62) | KDM4EMAPTNPSR1RECQLHSD17B10 | |
| SCHEMBL15887186 | 0.72 | KDM4E (0.62) | KDM4EMAPTNPSR1RECQLHSD17B10 | |
| SCHEMBL876284 | 0.71 | KDM4E (0.65) | KDM4EMAPTNPSR1RECQLHSD17B10 | |
| SCHEMBL875250 | 0.70 | RORC (0.38) | KDM4EMAPTTP53ALDH1A1HPGD | |
| SCHEMBL876287 | 0.70 | MAPT (0.35) | MAPTTP53MEN1KMT2ALMNA | |
| SCHEMBL2216295 | 0.69 | MAPT (0.58) | KDM4EMAPTNPSR1RECQLHSD17B10 | |
| SCHEMBL875212 | 0.68 | GUCY1B2 (0.34) | KDM4EMAPTHPGDMEN1KMT2A | |
| SCHEMBL875508 | 0.67 | PRSS1 (0.35) | MAPTTP53KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619202-A1 | PYRIDMIDONES FOR TREATMENT OF POTASSIUM CHANNEL RELATED DISEASES | Pfizer Inc (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012038850-A1 | PYRIDMIDONES FOR TREATMENT OF POTASSIUM CHANNEL RELATED DISEASES | PFIZER INC. (US) | 2012-03-29 | — | — | WO | disclosed |