Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8691572 | 0.75 | GRM2 (0.35) | GRM2 | |
| SCHEMBL6609808 | 0.75 | SIGMAR1 (0.41) | GRM2 | |
| SCHEMBL2688223 | 0.74 | GRIN2B (0.55) | GRM2 | |
| Hydrochloric Acid SCHEMBL9466555 | 0.74 | SIGMAR1 (0.41) | GRM2 | |
| SCHEMBL8303444 | 0.72 | SIGMAR1 (0.55) | CCR3 | |
| SCHEMBL6806817 | 0.72 | CCR3 (0.55) | KCNH2HRH3CCR3 | |
| SCHEMBL9179381 | 0.71 | ALDH1A1 (0.40) | — | |
| SCHEMBL9179397 | 0.71 | SIGMAR1 (0.55) | — | |
| SCHEMBL9173695 | 0.70 | ALDH1A1 (0.37) | HRH3 | |
| SCHEMBL9178363 | 0.69 | SIGMAR1 (0.41) | CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773937-A1 | NOVEL ARYL PIPERAZINE-DERIVED PIPERAZIDE DERIVATIVES, METHODS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | PIERRE FABRE MEDICAMENT (FR) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996002525-A1 | NOVEL ARYL PIPERAZINE-DERIVED PIPERAZIDE DERIVATIVES, METHODS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | PIERRE FABRE MEDICAMENT (FR) | 1996-02-01 | — | — | WO | disclosed |