Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 2/20 | 0.35 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.35 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.35 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9175467 | 0.93 | SIGMAR1 (0.40) | SIGMAR1GRIN2BHTR1ACCR3SLC6A4 | |
| SCHEMBL9179397 | 0.88 | SIGMAR1 (0.55) | SIGMAR1GRIN2BHTR1ADRD2DRD3 | |
| SCHEMBL2688223 | 0.83 | GRIN2B (0.55) | SIGMAR1GRIN2BHTR1A | |
| SCHEMBL9183292 | 0.82 | PREP (0.41) | SIGMAR1GRIN2B | |
| SCHEMBL1038534 | 0.82 | SIGMAR1 (0.43) | SIGMAR1 | |
| SCHEMBL8303444 | 0.81 | SIGMAR1 (0.55) | SIGMAR1CCR3DRD2HTR2B | |
| SCHEMBL9466307 | 0.80 | SIGMAR1 (0.51) | SIGMAR1 | |
| SCHEMBL9179381 | 0.79 | ALDH1A1 (0.40) | SIGMAR1GRIN2B | |
| SCHEMBL9467343 | 0.78 | SIGMAR1 (0.51) | SIGMAR1HTR1A | |
| SCHEMBL8304636 | 0.76 | OPRM1 (0.41) | HTR1ACCR3DRD2DRD3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490772-B1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |
| US-5194437-A | Substituted with oxygen containing heterocycle, central nervous system disorders, neuroendocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-03-16 | — | — | US | disclosed |
| EP-0490772-A1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-06-17 | — | — | EP | disclosed |