SCHEMBL8760122

SCHEMBL8760122

CCc1c(-c2ccccc2)n(COCC(O[SiH](C)C)C(C)(C)C)c(=S)[nH]c1=S

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 7/20 0.34
SIRT1 Q96EB6 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9353914 0.83 SIRT2 (0.37) SIRT2SIRT1
SCHEMBL9353732 0.82 SIRT2 (0.37) SIRT2SIRT1
SCHEMBL7213420 0.79 SIRT2 (0.41) SIRT2SIRT1
SCHEMBL9357392 0.78 ALDH1A1 (0.34) SIRT2
SCHEMBL9353926 0.77 SIRT2 (0.33) SIRT2SIRT1
SCHEMBL8760238 0.74 UPP1 (0.37) SIRT2SIRT1
SCHEMBL8760109 0.73 DUT (0.43) SIRT2SIRT1
SCHEMBL8761065 0.69
SCHEMBL7213422 0.67 SIRT2 (0.53) SIRT2SIRT1
SCHEMBL9354282 0.66 DUT (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0449726-B1 Pyrimidine nucleoside derivative and antiviral agent containing the derivative as active ingredient MITSUBISHI CHEM CORP (JP) 1997-06-11 EP disclosed
US-5318972-A Active against retroviruses, human t-cell leukemia/lymphoma viruses MITSUBISHI KASEI CORPORATION (JP) 1994-06-07 US disclosed
EP-0449726-A1 Pyrimidine nucleoside derivative and antiviral agent containing the derivative as active ingredient Mitsubishi Chemical Corporation (JP) 1991-10-02 EP disclosed