Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OXTR | P30559 | 8/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.61 |
| ▸ | CCKBR | P32239 | 8/20 | 0.56 |
| ▸ | CCKAR | P32238 | 2/20 | 0.53 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.51 |
| ▸ | RBPJ | Q06330 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8760307 | 0.89 | KCNH2 (0.76) | OXTRKCNH2CCKBRCCKARNOTCH1 | |
| SCHEMBL8462710 | 0.87 | KCNH2 (0.81) | OXTRKCNH2 | |
| SCHEMBL8761096 | 0.85 | OXTR (0.58) | OXTRKCNH2CCKBRCCKAR | |
| SCHEMBL8760280 | 0.85 | OXTR (0.58) | OXTRKCNH2CCKBRCCKAR | |
| SCHEMBL8761589 | 0.78 | KCNH2 (0.80) | OXTRKCNH2CCKBRCCKARNOTCH1 | |
| SCHEMBL9866216 | 0.78 | CCKBR (0.76) | OXTRKCNH2CCKBRCCKAR | |
| SCHEMBL8846371 | 0.77 | KCNH2 (0.79) | OXTRKCNH2 | |
| SCHEMBL8609474 | 0.77 | CCKBR (0.74) | KCNH2CCKBRCCKAR | |
| SCHEMBL8463081 | 0.77 | KCNH2 (0.85) | KCNH2CCKBR | |
| SCHEMBL4421095 | 0.77 | PSEN1 (0.82) | OXTRKCNH2CCKBRNOTCH1RBPJ |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0776203-A4 | N-2,3-DIHYDRO-1-(2-PROPYL)-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINES | MERCK & CO INC (US) | 1997-12-29 | — | — | EP | disclosed |
| EP-0776203-A1 | N-2,3-DIHYDRO-1-(2-PROPYL)-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINES | MERCK & CO. INC. (US) | 1997-06-04 | — | — | EP | disclosed |
| US-5633251-A | N-2,3-dihydro-1-(2-propyl)-2-oxo-5-phenyl-1h-1,4-benzodiazepines | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| WO-1996005827-A1 | N-2,3-DIHYDRO-1-(2-PROPYL)-2-OXO-5-PHENYL-1H-1,4-BENZODIAZEPINES | MERCK & CO., INC. (US) | 1996-02-29 | — | — | WO | disclosed |