Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 8/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8797099 | 1.00 | CHRM1 (0.50) | CHRM1ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL3401502 | 0.85 | SIGMAR1 (0.47) | CHRM1ALDH1A1KMT2AGAATSHR | |
| SCHEMBL8405468 | 0.81 | HPGD (0.52) | CHRM1ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL3596195 | 0.80 | CHRM1 (0.55) | CHRM1ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL8761484 | 0.79 | HTR1A (0.53) | CHRM1ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL8405067 | 0.79 | HTR1A (0.53) | CHRM1ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL20777488 | 0.79 | CHRM1 (0.48) | CHRM1ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL5680025 | 0.79 | HPGD (0.54) | CHRM1ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL8655841 | 0.78 | HTR1A (0.52) | CHRM1ALDH1A1HPGDKMT2AKDM4E | |
| SCHEMBL8783362 | 0.78 | CHRM1 (0.43) | CHRM1ALDH1A1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687257-B1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1997-06-18 | — | — | EP | disclosed |
| US-5610295-A | 4-amino-2-(hetero)aryl-butanamides useful as 5-HT1A -antagonists | JOHN WYETH & BROTHER, LTD. (GB) | 1997-03-11 | — | — | US | disclosed |
| US-5525600-A | COMPOUND USEFUL AS ANTIPSYCHOTIC, ANTIDEPRESSANT AND ANXIBLYTIC AGENTS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1996-06-11 | — | — | US | disclosed |
| EP-0687257-A1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1995-12-20 | — | — | EP | disclosed |
| WO-1994020481-A1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |