Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.43 |
| ▸ | DRD4 | P21917 | 5/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 4/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3088832 | 0.79 | DRD4 (0.54) | DRD2DRD4GRM5DRD3HTR1A | |
| SCHEMBL2321076 | 0.78 | DRD4 (0.49) | DRD2DRD4GRM5DRD3HTR1A | |
| SCHEMBL13898671 | 0.76 | MC4R (0.51) | DRD2DRD4GRM5DRD3MC4R | |
| SCHEMBL2321072 | 0.74 | DRD4 (0.49) | DRD2DRD4GRM5DRD3HTR1A | |
| SCHEMBL23277098 | 0.74 | KDM4E (0.58) | DRD2DRD4GRM5DRD3HTR1A | |
| SCHEMBL20156961 | 0.74 | DRD2 (0.49) | DRD2DRD4GRM5DRD3MC4R | |
| SCHEMBL20156862 | 0.72 | DRD2 (0.45) | DRD2DRD4GRM5DRD3MC4R | |
| SCHEMBL30406641 | 0.71 | AR (0.59) | DRD2DRD4GRM5DRD3HTR1A | |
| SCHEMBL829177 | 0.71 | AR (0.65) | DRD2DRD4GRM5HTR1AAR | |
| SCHEMBL2077260 | 0.71 | GRM5 (0.51) | DRD2DRD4GRM5DRD3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0773937-A1 | NOVEL ARYL PIPERAZINE-DERIVED PIPERAZIDE DERIVATIVES, METHODS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | PIERRE FABRE MEDICAMENT (FR) | 1997-05-21 | — | — | EP | disclosed |
| WO-1996002525-A1 | NOVEL ARYL PIPERAZINE-DERIVED PIPERAZIDE DERIVATIVES, METHODS FOR THEIR PREPARATION, THEIR USE AS DRUGS AND PHARMACEUTICAL COMPOSITIONS COMPRISING SAME | PIERRE FABRE MEDICAMENT (FR) | 1996-02-01 | — | — | WO | disclosed |