Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 11/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10575998 | 0.85 | HTR1A (0.52) | DPP7CHRM1HTR1AHTR1DHTR2B | |
| SCHEMBL10576172 | 0.84 | CHRM1 (0.51) | DPP7CHRM1HTR1AHTR1DHTR2B | |
| SCHEMBL27782430 | 0.77 | SMN1; SMN2 (0.58) | DPP7GAA | |
| SCHEMBL8405067 | 0.77 | HTR1A (0.53) | DPP7CHRM1HTR1AHTR1DHTR2B | |
| SCHEMBL9910968 | 0.77 | KCNQ2 (0.56) | CHRM1HTR1AHTR1DHTR2BGAA | |
| SCHEMBL8761484 | 0.77 | HTR1A (0.53) | DPP7CHRM1HTR1AHTR1DHTR2B | |
| SCHEMBL1589765 | 0.76 | HTR1A (0.53) | CHRM1HTR1AHTR1DHTR2BGAA | |
| SCHEMBL8655841 | 0.76 | HTR1A (0.52) | DPP7CHRM1HTR1AHTR1DHTR2B | |
| SCHEMBL8761469 | 0.75 | EPHX2 (0.52) | CHRM1HTR1AHTR1DHTR2BGAA | |
| SCHEMBL12702271 | 0.74 | CHRM3 (0.52) | CHRM1HTR1AHTR1DHTR2BGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687257-B1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1997-06-18 | — | — | EP | disclosed |
| US-5610295-A | 4-amino-2-(hetero)aryl-butanamides useful as 5-HT1A -antagonists | JOHN WYETH & BROTHER, LTD. (GB) | 1997-03-11 | — | — | US | disclosed |
| EP-0687257-A1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | WYETH JOHN & BROTHER LTD (GB) | 1995-12-20 | — | — | EP | disclosed |
| WO-1994020481-A1 | 4-AMINO-2-(HETERO)ARYL-BUTANAMIDES USEFUL AS 5-HT1A-ANTAGONISTS | JOHN WYETH & BROTHER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |