Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR3 | P25089 | 3/20 | 0.46 |
| ▸ | FPR2 | P25090 | 3/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HTR3A | P46098 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8764666 | 0.95 | SMN1; SMN2 (0.45) | FPR3FPR2RAD52SMN1; SMN2TP53 | |
| SCHEMBL8971745 | 0.80 | FPR3 (0.36) | FPR3FPR2RAD52SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL6584702 | 0.79 | FPR3 (0.52) | FPR3FPR2RAD52SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL8972332 | 0.79 | RAD52 (0.37) | FPR3FPR2RAD52SMN1; SMN2TP53 | |
| SCHEMBL8764645 | 0.74 | HRH3 (0.48) | FPR3FPR2RAD52SMN1; SMN2TP53 | |
| Hydrochloric Acid SCHEMBL8765083 | 0.73 | HRH3 (0.47) | FPR3FPR2RAD52SMN1; SMN2TP53 | |
| SCHEMBL27717222 | 0.73 | HRH3 (0.47) | RAD52SMN1; SMN2HRH3SIGMAR1KDM4E | |
| SCHEMBL441058 | 0.73 | HRH3 (0.61) | FPR3FPR2SMN1; SMN2HRH3SIGMAR1 | |
| SCHEMBL9322157 | 0.72 | HRH3 (0.45) | FPR3FPR2RAD52SMN1; SMN2TP53 | |
| SCHEMBL13202809 | 0.72 | RAD52 (0.61) | FPR3FPR2RAD52SMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420116-B1 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMA INC (US) | 1997-07-30 | — | — | EP | claimed |
| US-5217979-A | Substituted alkyl piperidines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-08 | — | — | US | claimed |
| EP-0420116-A2 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1991-04-03 | — | — | EP | claimed |
| EP-0420116-B1 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMA INC (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5217979-A | Substituted alkyl piperidines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0420116-A2 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1991-04-03 | — | — | EP | disclosed |