Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FPR3 | P25089 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | RAD52 | P43351 | 1/20 | 0.35 |
| ▸ | GNAI3 | P08754 | 2/20 | 0.32 |
| ▸ | GNAO1 | P09471 | 2/20 | 0.32 |
| ▸ | GNAI1 | P63096 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CCR3 | P51677 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8972332 | 0.99 | RAD52 (0.37) | FPR3FPR2TP53SMN1; SMN2RAD52 | |
| SCHEMBL8972506 | 0.81 | GNAI3 (0.37) | FPR3FPR2TP53SMN1; SMN2RAD52 | |
| SCHEMBL8763757 | 0.80 | FPR3 (0.46) | FPR3FPR2TP53SMN1; SMN2RAD52 | |
| Hydrochloric Acid SCHEMBL8972944 | 0.80 | GNAI3 (0.39) | FPR3FPR2TP53SMN1; SMN2RAD52 | |
| SCHEMBL8972354 | 0.77 | TP53 (0.45) | FPR3FPR2TP53SMN1; SMN2 | |
| SCHEMBL8764666 | 0.76 | SMN1; SMN2 (0.45) | FPR3FPR2TP53SMN1; SMN2RAD52 | |
| Hydrochloric Acid SCHEMBL8972193 | 0.76 | TP53 (0.44) | FPR3FPR2TP53SMN1; SMN2RAD52 | |
| SCHEMBL8971755 | 0.74 | DDAH1 (0.35) | GNAI3GNAO1GNAI1 | |
| Hydrochloric Acid SCHEMBL8972341 | 0.73 | HRH3 (0.35) | GNAI3GNAO1GNAI1 | |
| SCHEMBL8972329 | 0.71 | GNAI3 (0.41) | SMN1; SMN2GNAI3GNAO1GNAI1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468457-B1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL DOW PHARMA (US) | 1996-03-06 | — | — | EP | claimed |
| EP-0468457-A1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | claimed |
| EP-0468457-B1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL DOW PHARMA (US) | 1996-03-06 | — | — | EP | disclosed |
| EP-0468457-A1 | Novel substituted piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | disclosed |