Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | FPR3 | P25089 | 1/20 | 0.42 |
| ▸ | FPR2 | P25090 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8763757 | 0.95 | FPR3 (0.46) | SMN1; SMN2TP53FPR3FPR2RAD52 | |
| SCHEMBL8971745 | 0.76 | FPR3 (0.36) | SMN1; SMN2TP53FPR3FPR2RAD52 | |
| Hydrochloric Acid SCHEMBL8972332 | 0.75 | RAD52 (0.37) | SMN1; SMN2TP53FPR3FPR2RAD52 | |
| Hydrochloric Acid SCHEMBL6584702 | 0.75 | FPR3 (0.52) | SMN1; SMN2TP53FPR3FPR2RAD52 | |
| SCHEMBL9329964 | 0.74 | SCN5A (0.50) | SMN1; SMN2TP53FPR3FPR2HRH3 | |
| SCHEMBL20363769 | 0.73 | L3MBTL1 (0.44) | SMN1; SMN2TP53MAPK1HRH3ALDH1A1 | |
| SCHEMBL17525451 | 0.73 | HRH3 (0.46) | SMN1; SMN2TP53TSHRHRH3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL9322363 | 0.72 | SCN5A (0.49) | SMN1; SMN2TP53FPR3FPR2RAD52 | |
| SCHEMBL172955 | 0.72 | HRH3 (0.56) | SMN1; SMN2CYP1A2MAPK1HRH3MEN1 | |
| SCHEMBL439729 | 0.72 | HRH3 (0.56) | SMN1; SMN2CYP1A2MAPK1HRH3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0420116-B1 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMA INC (US) | 1997-07-30 | — | — | EP | claimed |
| US-5217979-A | Substituted alkyl piperidines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-08 | — | — | US | claimed |
| EP-0420116-A2 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1991-04-03 | — | — | EP | claimed |
| EP-0420116-B1 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMA INC (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5217979-A | Substituted alkyl piperidines | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-06-08 | — | — | US | disclosed |
| EP-0420116-A2 | Novel substituted alkyl piperidines and their use as inhibitors of cholesterol synthesis | MERRELL PHARMACEUTICALS INC. (US) | 1991-04-03 | — | — | EP | disclosed |