Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.47 |
| ▸ | RELA | Q04206 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7912407 | 0.89 | NPC1 (0.65) | NPC1RAB9AHIF1APTGS2KMT2A | |
| SCHEMBL23401483 | 0.83 | NPC1 (0.59) | NPC1RAB9AHIF1AMCHR1PTGS2 | |
| SCHEMBL23399782 | 0.83 | PTGS2 (0.52) | NPC1RAB9AHIF1AMCHR1PTGS2 | |
| SCHEMBL12854139 | 0.80 | HIF1A (0.69) | NPC1RAB9AHIF1APTGS2KMT2A | |
| SCHEMBL31276556 | 0.80 | LMNA (0.58) | NPC1RAB9AHIF1APTGS2KMT2A | |
| SCHEMBL8765024 | 0.78 | RAB9A (0.69) | NPC1RAB9AHIF1APTGS2KMT2A | |
| SCHEMBL5698667 | 0.77 | NPC1 (0.56) | NPC1RAB9APTGS2KMT2AHSP90AA1 | |
| SCHEMBL5907375 | 0.77 | PTGS2 (0.68) | NPC1RAB9AHIF1APTGS2KMT2A | |
| SCHEMBL23401411 | 0.77 | NPC1 (0.68) | NPC1RAB9AHIF1AMCHR1PTGS2 | |
| SCHEMBL23402733 | 0.77 | NPC1 (0.55) | NPC1RAB9AHIF1APTGS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0731794-B1 | 1,4,5-TRIPHENYL PYRAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND INFLAMMATION-RELATED DISORDERS | SEARLE & CO (US) | 1997-08-06 | — | — | EP | disclosed |
| US-5639777-A | 1,4,5-triphenyl pyrazolyl compounds for the treatment of inflammation and inflammation-related disorders | G.D. SEARLE & CO. (US) | 1997-06-17 | — | — | US | disclosed |
| US-5401765-A | FOR TREATING ARTHRITIS, PAIN AND FEVER | Searle, G. D. (US) | 1995-03-28 | — | — | US | disclosed |