Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.47 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25883310 | 0.93 | PTGS2 (0.68) | PTGS2ALDH1A1PTGS1NPC1RAB9A | |
| SCHEMBL5907383 | 0.83 | PTGS2 (0.51) | PTGS2ALDH1A1PTGS1NR3C1NPC1 | |
| SCHEMBL6344616 | 0.82 | PTGS2 (1.00) | PTGS2PTGS1CYP2C9 | |
| SCHEMBL5734709 | 0.79 | PTGS2 (0.47) | PTGS2ALDH1A1PTGS1NR3C1NPC1 | |
| SCHEMBL8764353 | 0.77 | NPC1 (0.62) | PTGS2ALDH1A1PTGS1NPC1RAB9A | |
| SCHEMBL5431907 | 0.76 | ALDH1A1 (0.49) | PTGS2ALDH1A1NPC1RAB9AHIF1A | |
| SCHEMBL7912407 | 0.76 | NPC1 (0.65) | PTGS2ALDH1A1PTGS1NPC1RAB9A | |
| SCHEMBL31276388 | 0.75 | LMNA (0.53) | PTGS2ALDH1A1PTGS1NR3C1NPC1 | |
| SCHEMBL23399782 | 0.75 | PTGS2 (0.52) | PTGS2ALDH1A1PTGS1NPC1RAB9A | |
| SCHEMBL5907322 | 0.75 | PTGS2 (0.47) | PTGS2ALDH1A1PTGS1NR3C1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060264419-A1 | Substituted pyrazoles | MERCK PATENT GMBH (DE) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264419-A1 | Substituted pyrazoles | HTR3A, HTR1A, HTR1D | PTGS2 2319/4885ALDH1A1 1287/4885PTGS1 887/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.