SCHEMBL8764860

SCHEMBL8764860

Nc1onc(C(F)(F)F)c1Cl

nearest known ligand 0.44

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
MLYCD O95822 1/20 0.44
NOTUM Q6P988 1/20 0.31
BRD4 O60885 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7856794 0.70 MLYCD (0.38) MLYCDBRD4
SCHEMBL5157964 0.67
SCHEMBL11263501 0.66 MLYCD (0.51) MLYCD
SCHEMBL6610363 0.64 MLYCD (0.33) MLYCDBRD4
SCHEMBL10503592 0.62 MLYCD (0.64) MLYCDBRD4
SCHEMBL7857448 0.62 MLYCD (0.36) MLYCD
SCHEMBL4757756 0.62 LMNA (0.51) MLYCDNOTUM
SCHEMBL5156667 0.62 BRD4 (0.32) MLYCDBRD4
SCHEMBL8765219 0.61 MLYCD (0.35) MLYCDBRD4
SCHEMBL17054324 0.60 ALDH1A1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0375670-B1 Process for preparing 3-polyfluoroalkylisoxazolylamines SHIONOGI & CO (JP) 1997-08-06 EP disclosed
EP-0375670-A2 Process for preparing 3-polyfluoroalkylisoxazolylamines SHIONOGI & CO., LTD. (JP) 1990-06-27 EP disclosed
US-4797492-A INTERMEDIATES FOR BACTERICIDES; HERBICIDES OR FUNGICIDES SHIONOGI & CO., LTD. (JP) 1989-01-10 US disclosed
EP-0220947-A2 Polyfluoroalkylisoxazolylamines, their preparation and use SHIONOGI & CO., LTD. (JP) 1987-05-06 EP disclosed