Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLA1 | P09884 | 1/20 | 0.48 |
| ▸ | MGMT | P16455 | 3/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 10/20 | 0.41 |
| ▸ | CDK1 | P06493 | 8/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 7/20 | 0.41 |
| ▸ | CCNB3 | Q8WWL7 | 7/20 | 0.41 |
| ▸ | STAT3 | P40763 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8764937 | 0.86 | MAPT (0.48) | MGMTLRRK2MAPTCDK1STAT3 | |
| SCHEMBL3072990 | 0.74 | GDA (0.67) | — | |
| SCHEMBL8764928 | 0.71 | CDK8 (0.37) | MAPTCDK2 | |
| SCHEMBL9503859 | 0.70 | PDPK1 (0.56) | POLA1MGMTPDPK1CDK2CDK1 | |
| SCHEMBL3303363 | 0.68 | PIN1 (0.59) | MGMTCDK2CDK1CCNB1CCNA2 | |
| SCHEMBL30677864 | 0.68 | PDPK1 (0.58) | POLA1MGMTPDPK1CDK2CDK1 | |
| Methylguanine SCHEMBL231097 | 0.67 | CDK1 (0.69) | MGMTPDPK1CDK2CDK1CCNB1 | |
| SCHEMBL1443987 | 0.67 | PDPK1 (0.56) | POLA1PDPK1CDK2CDK1CCNB1 | |
| Methylguanine SCHEMBL29903462 | 0.67 | CDK1 (0.69) | MGMTPDPK1CDK2CDK1CCNB1 | |
| SCHEMBL7108861 | 0.65 | POLA1 (1.00) | POLA1MAPTCDK2CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0461407-B1 | Improved process for the preparation of 2-amino(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)adenine | ASH STEVENS INC (US) | 1997-07-30 | — | — | EP | disclosed |
| US-5206351-A | PROCESS FOR THE PREPARATION OF 2-AMINO (2,3,5-TRI-O-BENZYL-BETA-D-ARABINOFURANOSYL)ADENINE | ASH STEVENS, INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0461407-A1 | Improved process for the preparation of 2-amino(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)adenine | ASH STEVENS, INC. (US) | 1991-12-18 | — | — | EP | disclosed |