Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CDK9 | P50750 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25921184 | 0.82 | GAA (0.56) | HPGDALDH1A1TSHRKDM4EGAA | |
| SCHEMBL8764937 | 0.80 | MAPT (0.48) | MAPT | |
| SCHEMBL9021288 | 0.77 | CYP1A2 (0.40) | ALDH1A1KDM4ECYP2C19RAB9A | |
| SCHEMBL8764949 | 0.71 | POLA1 (0.48) | CDK2MAPT | |
| SCHEMBL9412566 | 0.69 | KDM4E (0.35) | ALDH1A1KDM4EGAAMAPTSMN1; SMN2 | |
| SCHEMBL9412739 | 0.69 | MAPT (0.35) | ALDH1A1KDM4EGAAMAPTSMN1; SMN2 | |
| SCHEMBL8121389 | 0.69 | BRD4 (0.51) | HPGDHTT | |
| SCHEMBL11876693 | 0.68 | XDH (0.39) | CDK2 | |
| SCHEMBL27157690 | 0.68 | LMNA (0.33) | HPGDALDH1A1KDM4E | |
| SCHEMBL19979158 | 0.68 | XDH (0.43) | CDK8ALDH1A1CDK2CDK9KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0461407-B1 | Improved process for the preparation of 2-amino(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)adenine | ASH STEVENS INC (US) | 1997-07-30 | — | — | EP | disclosed |
| EP-0456817-B1 | PROCESS FOR THE PREPARATION OF 2-AMINO-9-(2,3,5-TRI-0-BENZYL-BETA-D-ARABINOFURANOSYL)ADENINE AND NOVEL INTERMEDIATES | ASH STEVENS INC (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5206351-A | PROCESS FOR THE PREPARATION OF 2-AMINO (2,3,5-TRI-O-BENZYL-BETA-D-ARABINOFURANOSYL)ADENINE | ASH STEVENS, INC. (US) | 1993-04-27 | — | — | US | disclosed |
| US-5110919-A | Economical preparation of nucleosides | ASH STEVENS, INC. (US) | 1992-05-05 | — | — | US | disclosed |
| EP-0456817-A4 | PROCESS FOR THE PREPARATION OF 2-AMINO-9-(2,3,5-TRI-0-BENZYL-BETA-D-ARABINOFURANOSYL)ADENINE AND NOVEL INTERMEDIATES | — | 1992-04-22 | — | — | EP | disclosed |
| EP-0461407-A1 | Improved process for the preparation of 2-amino(2,3,5-tri-O-benzyl-beta-D-arabinofuranosyl)adenine | ASH STEVENS, INC. (US) | 1991-12-18 | — | — | EP | disclosed |
| EP-0456817-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-9-(2,3,5-TRI-0-BENZYL-BETA-D-ARABINOFURANOSYL)ADENINE AND NOVEL INTERMEDIATES. | ASH STEVENS INC (US) | 1991-11-21 | — | — | EP | disclosed |
| WO-1991008215-A1 | PROCESS FOR THE PREPARATION OF 2-AMINO-9-(2,3,5-TRI-0-BENZYL-BETA-D-ARABINOFURANOSYL)ADENINE AND NOVEL INTERMEDIATES | ASH STEVENS, INC. (US) | 1991-06-13 | — | — | WO | disclosed |