Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.45 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | RXRG | P48443 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | THRA | P10827 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 1/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ESRRA | P11474 | 1/20 | 0.39 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.39 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.39 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3900976 | 0.86 | TTR (0.64) | TTRARKIF11LPAR1LPAR5 | |
| SCHEMBL1685381 | 0.78 | LTA4H (0.46) | RXRARXRBRXRGMRGPRX4PPARG | |
| SCHEMBL79041 | 0.78 | RXRA (0.56) | RXRARXRBRXRGMRGPRX4S1PR1 | |
| SCHEMBL1437536 | 0.78 | S1PR1 (0.58) | RXRARXRBRXRGARKIF11 | |
| SCHEMBL31435356 | 0.78 | S1PR1 (0.58) | RXRARXRBRXRGARKIF11 | |
| SCHEMBL883499 | 0.78 | EPAS1 (0.49) | TTRRXRARXRBRXRGAR | |
| SCHEMBL9889486 | 0.77 | AR (0.48) | TTRARCYP3A4NR1H2NR1H3 | |
| SCHEMBL2020809 | 0.77 | S1PR1 (0.47) | RXRARXRBRXRGARMRGPRX4 | |
| SCHEMBL10088933 | 0.77 | S1PR1 (0.44) | RXRARXRBRXRGARMRGPRX4 | |
| SCHEMBL11048002 | 0.76 | LTA4H (0.45) | RXRARXRBRXRGARMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619203-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES | Glaxo Group Limited (GB) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012037782-A1 | TRICYCLIC COMPOUNDS, PREPARATION METHODS, AND THEIR USES | GLAXO GROUP LIMITED (GB) | 2012-03-29 | — | — | WO | disclosed |