Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 1/20 | 0.45 |
| ▸ | PRKACA | P17612 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | CDK9 | P50750 | 1/20 | 0.45 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.45 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17079721 | 0.90 | IGF1R (0.53) | PDGFRAPRKACAKDRCDK8CDK9 | |
| SCHEMBL27490808 | 0.79 | SIGMAR1 (0.45) | SIGMAR1TAAR1CYP11B2MEN1CYP3A4 | |
| SCHEMBL9453770 | 0.79 | SIGMAR1 (0.47) | SIGMAR1TAAR1CYP11B2MEN1CYP3A4 | |
| SCHEMBL8015745 | 0.78 | CYP19A1 (0.52) | DDB1CRBNCYP3A4GRIN2B | |
| SCHEMBL29390302 | 0.77 | SIGMAR1 (0.62) | PDGFRAPRKACAKDRCDK8CDK9 | |
| SCHEMBL503849 | 0.77 | SIGMAR1 (0.62) | PDGFRAPRKACAKDRCDK8CDK9 | |
| SCHEMBL9628237 | 0.76 | GID4 (0.33) | IGF1RALOX15DDB1CRBN | |
| SCHEMBL30606845 | 0.76 | SIGMAR1 (0.60) | PDGFRAPRKACAKDRCDK8CDK9 | |
| SCHEMBL28025940 | 0.76 | SIGMAR1 (0.60) | PDGFRAPRKACAKDRCDK8CDK9 | |
| Ammonia Solution, Strong SCHEMBL8210515 | 0.76 | SIGMAR1 (0.60) | PDGFRAPRKACAKDRCDK8CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0147909-B1 | ARYLOXY-N-(AMINOALKYL)-1-PYRROLIDINE AND PIPERIDINE CARBOXAMIDES AND CARBOTHIOAMIDES HAVING ANTIARRHYTHMIC ACTIVITY | A.H. ROBINS COMPANY, INCORPORATED (US) | 1989-12-06 | — | — | EP | claimed |
| EP-0777680-A1 | UROKINASE RECEPTOR LIGANDS | CHIRON CORPORATION (US) | 1997-06-11 | — | — | EP | disclosed |
| WO-1996040747-A1 | UROKINASE RECEPTOR LIGANDS | CHIRON CORPORATION (US) | 1996-12-19 | — | — | WO | disclosed |