Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.37 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.37 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8767339 | 0.96 | HTT (0.38) | PKMHTTLMNANPC1RAB9A | |
| SCHEMBL8766432 | 0.81 | HTT (0.40) | HTTLMNANPC1RAB9AADRA1D | |
| SCHEMBL8772451 | 0.81 | LMNA (0.40) | PKMHTTLMNA | |
| SCHEMBL9109323 | 0.77 | CYSLTR2 (0.47) | SOAT2ACAT1SOAT1CYSLTR2CYSLTR1 | |
| SCHEMBL9109873 | 0.77 | CYSLTR2 (0.47) | SOAT2ACAT1SOAT1CYSLTR2CYSLTR1 | |
| SCHEMBL8767579 | 0.77 | PKM (0.40) | PKMHTTLMNAADRA1DADRA1A | |
| SCHEMBL8767314 | 0.75 | PKM (0.38) | PKMHTTLMNAADRA1DADRA1A | |
| SCHEMBL8767413 | 0.74 | PKM (0.37) | PKMHTTLMNAADRA1DADRA1A | |
| SCHEMBL14602856 | 0.74 | PDPK1 (0.51) | SOAT2ACAT1SOAT1NPC1CYSLTR2 | |
| SCHEMBL28937529 | 0.74 | PDPK1 (0.51) | SOAT2ACAT1SOAT1NPC1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |